• Intermolecular Forces
• Molecular Geometry
• Hybridization, Double Bond Geometry
• Aromatic Electronic Structure
• Vapor Pressure
• Kinetic Energy Molecular Distribution

• Medicinal Chemistry: Chapter 2 
• Kotz: 9.8-9.9,13.1-13.5, 14.2,14.5
• CHEMGUIDE Bonding Menu

• Solubility and Thermodynamics
• Log P (Octanol-Water Partition Coefficient)
• Surfactants and Soaps
• Phospholipid Structure & Components
• Membrane Structure and Properties

• Medicinal Chemistry: Chapter 2
• Log P & Partition Coefficent
• Kimball "Phospholipids"
• Kimball "Cell Membranes"
• UCSF "Membrane Tutorial"

Alcohols and Carboxylic Acids

Triglyceride Formation

Peptide Formation and Hydrolysis

Polyphosphate Formation

• Medicinal Chemistry: Chapter 2

• Types of Side Chains
• Henderson-Hasselbalch Equation
• Charge and pH
• Isoelectric Points

• Medicinal Chemistry: Chapter 3

• Peptide Bond Geometry and Resonance
• Protein Primary Structure and Disulfide Bonds
• Secondary Structure - Alpha Helices, Beta Sheets
• Key Interactions for Protein Folding, Prions
• Post-Translational Protein Modications

• Medicinal Chemistry: Chapter 3
• "Protein Structure and ATP"
• Proteins

Enzymes as Drug Targets I
(Reaction kinetics, equilibrium constants, binding interactions)
• Arrhenius Reaction Model
• Transition states, Activation Energy, Catalysis
• Enzyme-Substrate Interactions, Active Sites
• Enzyme Inhibition

• Medicinal Chemistry: Chapter 4
• Enzymes
• Enzyme Kinetics
• Enzyme Kinetics Tutorial

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Enzymes as Drug Targets II
(Enzyme Kinetics)
• Michaelis-Menton equation
• Michaelis Constant, Dissociation Constant
• Lineweaver-Burk Plots
• Turnover Number, Vmax

• Medicinal Chemistry: Chapter 4

• Michaelis-Menton equation
• Michaelis Constant, Dissociation Constant
• Lineweaver-Burk Plots
• Turnover Number, Vmax

• Neurotransmittors and Hormones
• Receptors: Ion Channels & Membrane Receptors
• Receptor-Ligand Interactions
• Agonists and Antagonists
• Sensitization, Tolerance, and Dependence

• Medicinal Chemistry: Chapter 5

• Affinity, Efficacy, & Potency
• Dissociation Binding Equilibria
• EC50, IC50
• Scatchard Plots

• Medicinal Chemistry: Chapter 5

• Ion Channels
• G-Protein Coupled Receptors
• Kinase-Linked Receptors
• Intracellular Receptors 

• Medicinal Chemistry: Chapter 6

• Ion Concentration Gradients
• Membrane Potentials
• Inhibitory and Excitatory Changes

• Handout

• Phosphorylation
• GPCR Signal Transduction Pathways
• Intracellular Receptors
• Zinc Fingers

• Medicinal Chemistry: Chapter 6

• Arachidonic Acid Initiated Inflammation
• Mechanism of Action for COX Inhibitors
• Structure of Nonspecific COX Inhibitors
• COX-2 Inhibitors

• "Cyclooxygenase" from "Protein Function"
• UM NSAID PowerPoint Lecture
• "Cox in a Crystal Ball" JCI article
• David Graham's COX-2 FDA Memo

Steroids

• Steroid Structures and Properties
• Roles as Hormones
• Steroidal Anti-Inflammatory Mechanism of Action
• Zinc Finger Steroid Receptors

• Steroid Handout 

• Cholinergic System
• Acetylcholine: Structure, Receptor Binding

• Medicinal Chemistry: Chapter 19

• Cholinergic Antagonists
• Acetylcholinesterase Inhibitors

• Medicinal Chemistry: Chapter 19

• Medicinal Chemistry: Chapter 20

• Medicinal Chemistry: Chapter 20

• Handout

• Handout

• Medicinal Chemistry: Chapter 21

• Anesthetics and Opioid Analgesics Handout