General Chemistry II Course Competencies
Lsn 1: Intro to Drug Targets and Interactions I (Intermolecular
Forces, Molecular Structure, Lewis Structures)
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Electronegativity, charge distribution, and molecular bonding structure
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Understand how to use relative electronegativities of atoms to clearly
depict charge distribution across chemical bonds. Be able to quickly
predict partial charges on atoms within given molecules.
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Noncovalent interactions and intermolecular forces
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Understand and be able to clearly discuss and diagram the basis for attractions
between molecules/ions to include ion hydration, hydrogen bonding, London
dispersion, dipole-dipole, ion-dipole, and cation-p
electron
interactions.
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Understand and use the relative magnitude (in kJ/mole) of chemical bonds
(e.g. ionic, covalent and metallic) vs intermolecular forces (hydrogen
bonding, London dispersion, dipole/dipole) interactions.
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Quickly draw diagrams that clearly show appropriate partial charges and
intermolecular interactions among a given set of molecules or ions.
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Predict points of potential H-bond donors and acceptors for any given molecular
structure.
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Predict and discuss relative boiling points (also vapor pressure, melting
points, viscosity, surface tension) from molecular structure
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Molecular structure
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Draw molecular structures showing all bonds from a given molecular representation
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Quickly draw Lewis structures for a given molecule or ion
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Predict electron arrangement, molecular geometry, hybridization, and bond
angles around given atoms in molecules
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Multiple bond structure
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Outline, discuss, and use aromatic electronic structure and geometry
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Know and discuss double/triple bond geometry and hybridization
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Outline and diagram cis/trans geometry about carbon-carbon double bonds
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Molecules: carboxylic acids, fatty acids, amino acids, and alkaloids
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Outline the structure of a carboxylic acid functional group and diagram
its acid/conjugate base forms
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Be able to draw the structure for fatty acids, to include those having
one or more points of unsaturation
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Distribution of molecular kinetic energies
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Calculate fractions of molecules having kinetic energies greater than a
given energy at a given temperature
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Graphically represent and be able to clearly explain the distribution of
kinetic energies of a collection of molecules at various temperatures
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Understand kinetic energy conversion into potential energy to separate
molecules, to break bonds, or to react molecules