General Chemistry II Course
Competencies
Lsn 8: Receptors as Drug Targets I
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Know the molecular structures for these neurotransmitters:
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Cathecholamines: L-Dopa, dopamine, norepinephrine, and epinephrine
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Amino Acids: Glutamate, Aspartate, Glycine, GABA (gamma-aminobutyric acid)
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Understand how PCP (angel dust) and Memantine (Namenda) affect the glutamate
receptor NMDA (N-Methyl-D-Aspartate)
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Understand the synthesis steps involved in the production of L-DOPA, dopamine,
norepinephrine, and epinephrine
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Understand the role of glycine and GABA receptors
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Be able to explain the electrochemical basis for their inhibitory effects
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Clearly explain how each of the following substances affects the GABA-ergic
system: ethanol, barbiturates, strychnine, diazepam (valium), and caffeine
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Explain the role of monoamine oxidase (MAO) for catecholamine neurotransmitters;
identify the role of MAO inhibitors.
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Explain the effect of dopamine levels on brain activity
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Explain the effects of cocaine and of amphetamines on the dopaminergic
system
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Outline the role of seratonin and identify the substance from which it
is produced
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Explain what SSRI's are and what they are used for