Lsn 12:  Receptor Structure and Signal Transduction II

Intracellular Receptors and Zinc fingers

• Diagram and effectively discuss the structure of zinc fingers; clearly show the amino acid residues that interact with the zinc ion and how zinc fingers affect protein shape
• Explain the underlying basis for the zinc finger mechanism of action in steroidal interactions with DNA
• Discuss a new area of drug research that targets the zinc fingers in estrogen receptors to treat breast cancer