General Chemistry II Course
Competencies
Lsn 6: Enzymes as Drug Targets I (Reaction
kinetics, equilibrium constants, binding interactions)
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Chemical kinetics
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Understand the two fundamental requirements for a chemical reaction to
occur…
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Draw reaction coordinate-energy profiles and clearly label activation energies,
and heat gained or lost
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Understand and be able to clearly explain the role of catalysts
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Understand and be able to use fundamental principles to clearly describe
the dependence of reaction rate changes with temperature
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Arrehenius equation
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Know and be able to use the Arrehenius equation for rate constant determination
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Demonstrated the ability to calculate relative rates of reactions for different
activation energies or temperatures
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Understand how to experimentally determine a reaction's activation energy
using Arrhenius plots
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Understand relative impacts of temperature changes on rates for chemical
reactions with low and high activation energies
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Be able to use activiation energies to predict rate constants at different
temperatures
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Rate law
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Understand what is meant by the rate law and outline the experimental procedures
and methodology to determine reaction order
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Use a given rate law to calculate rate constants and their associated units
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Enzyme-substrate interactions
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Be able to draw and to clearly explain reaction energy diagrams for enzyme-substrate
interactions
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Understand the effects of inhibitors and what is specifically meant by
IC50
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Understand and clearly explain the basis for important types of noncovalent
enzyme-substrate interactions
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Clearly describe the enzyme inhibition process