Date
(Competencies)
|
Topic
|
Readings
|
1/9
Competencies
Lsn 1
|
Intro to Drug Targets and
Interactions I
(Intermolecular
Forces, Molecular Structure, Lewis Structures)
- Intermolecular Forces
- Molecular Geometry
- Hybridization, Double
Bond Geometry
- Aromatic Electronic
Structure
- Vapor Pressure
- Kinetic Energy
Molecular Distribution
|
|
1/11
Competencies
Lsn 2
PS1 Due
|
Intro to Drug Targets and
Interactions II
(Solubility, log P
Calculations, Phospholipids, Membranes)
- Solubility and
Thermodynamics
- Log P (Octanol-Water
Partition Coefficient)
- Surfactants and Soaps
- Phospholipid
Structure & Components
- Membrane Structure
and Properties
|
|
1/16
Competencies
Lsn 3
PS2 Due
|
Intro to Drug Targets and
Interactions III
(Condensation and
Hydrolysis Reactions)
· Alcohols and Carboxylic
Acids
· Triglyceride Formation
· Peptide Formation and
Hydrolysis
· Polyphosphate Formation
|
- Medicinal Chemistry: Chapter 2
|
1/18
Competencies
Lsn 4
PS3 Due
|
Proteins as Drug Targets I
(Amino Acids,
Acid-Base Properties, Henderson-Hasselbalch)
- Types of Side Chains
- Henderson-Hasselbalch
Equation
- Charge and pH
- Isoelectric Points
|
- Medicinal Chemistry: Chapter 3
|
1/23
Competencies
Lsn 5
PS4 Due
|
Proteins as Drug Targets
II
(Protein
structure)
- Peptide Bond Geometry
and Resonance
- Protein Primary
Structure and Disulfide Bonds
- Secondary Structure -
Alpha Helices, Beta Sheets
- Key Interactions for
Protein Folding, Prions
- Post-Translational
Protein Modications
|
- Medicinal Chemistry: Chapter 3
- "Protein
Structure and ATP"
- Proteins
|
1/25
Competencies
Lsn 6
|
Enzymes as Drug Targets I
(Reaction
kinetics, equilibrium constants, binding interactions)
- Arrhenius Reaction
Model
- Transition states,
Activation Energy, Catalysis
- Enzyme-Substrate
Interactions, Active Sites
- Enzyme Inhibition
|
|
1/30
Competencies
Lsn 7
|
Enzymes as Drug Targets II
(Enzyme
Kinetics)
- Michaelis-Menton
equation
- Michaelis Constant,
Dissociation Constant
- Lineweaver-Burk Plots
- Turnover Number, Vmax
|
- Medicinal Chemistry: Chapter 4
|
2/6
Competencies Lsn 7
|
Enzymes as Drug Targets
III
(Enzyme
Kinetics)
- Michaelis-Menton
equation
- Michaelis Constant,
Dissociation Constant
- Lineweaver-Burk Plots
- Turnover Number, Vmax
|
|
|
2/8
Competencies
Lsn 8
|
Receptors as Drug Targets
I
- Neurotransmittors and
Hormones
- Receptors: Ion
Channels & Membrane Receptors
- Receptor-Ligand
Interactions
- Agonists and
Antagonists
- Sensitization,
Tolerance, and Dependence
|
- Medicinal Chemistry: Chapter 5
|
|
2/13
Competencies
Lsn 9
|
Receptors as Drug Targets
II
- Affinity, Efficacy,
& Potency
- Dissociation Binding
Equilibria
- EC50, IC50
- Scatchard Plots
|
- Medicinal Chemistry: Chapter 5
|
|
2/20
Competencies
Lsn 10
|
Receptor Structure and
Signal Transduction I
- Ion Channels
- G-Protein Coupled
Receptors
- Kinase-Linked
Receptors
- Intracellular
Receptors
|
- Medicinal Chemistry: Chapter 6
|
|
2/22
Competencies Lsn 11
|
Receptor Structure &
Signal Transduction II
- Phosphorylation
- GPCR Signal
Transduction Pathways
- Intracellular
Receptors
- Zinc Fingers
|
|
|
2/27
|
Test #1
|
|
|
3/1
Lsn 14
|
Thermodynamics of Ion
Channels
- Ion Concentration
Gradients
- Membrane Potentials
- Inhibitory and
Excitatory Changes
|
|
|
3/6
|
Electrochemistry &
Thermodynamics I
|
|
|
3/8
PS5 Due
|
Electrochemistry &
Thermodynamics II
|
|
|
3/20
Competencies Lsn 19
|
Cholinergics I
- Cholinergic System
- Acetylcholine:
Structure, Receptor Binding
|
- Medicinal Chemistry: Chapter 19
|
|
3/22
Competencies
Lsn 20
|
Cholinergics II
- Cholinergic
Antagonists
- Acetylcholinesterase
Inhibitors
|
- Medicinal Chemistry: Chapter 19
|
|
3/27
Competencies
Lsn 21
|
Adrenergics I
|
- Medicinal Chemistry: Chapter 20
|
|
3/29
Competencies
Lsn 22
|
Adrenergics II
|
- Medicinal Chemistry: Chapter 20
|
|
4/3
Competencies
Lsn 23
|
Psychoactive Drugs I
|
|
|
4/5
Competencies
Lsn 24
|
Psychoactive Drugs II
|
|
|
4/10
Competencies
Lsn 25
|
Opium and Opioid
Analgesics
|
- Medicinal Chemistry: Chapter 21
|
|
4/12
Competencies
Lsn 26
|
Chemistry of Local &
General Anesthetics
|
- Anesthetics and
Opioid Analgesics Handout
|
|
4/17
Lsn 27
|
Test 2
|
|
|
4/19
Lsn 28
|
Review
|
|
|