General Chemistry II Spring 2006 Course Syllabus
Date
 (Competencies)
Topic 
Readings
1/10
Competencies Lsn 1
General Chemistry I Review
  • Electronegativity & Coulomb’s Law
  • Intermolecular Forces
  • Solubility
  • Hydrophobic/Hydrophilic Substances
  • Vapor Pressure
  • Kinetic Energy Molecular Distribution
1/12
Competencies Lsn 2
General Chemistry I Review
  • Molecular Geometry
  • Hybridization
  • Double Bond Geometry
  • Aromatic Electronic Structure
  • Fatty Acids, Amino Acids, Alkaloids, Glycerol
  • Kotz: 10.2,11.3-11.4,pp 531-532
1/17
Competencies Lsn 3
Condensation and Hydrolysis Reactions
  • Reaction between Alcohols and Carboxylic Acids
  • Triglyceride Formation
  • Peptide Formation and Hydrolysis
  • Polyphosphate Formation
1/19
Competencies Lsn 4
Phospholipids and Membranes
  • Phospholipid Formation and Structure
  • Surfactants and Soaps
  • Membrane Structure and Properties
1/24
Competencies Lsn 5
Amino Acids and their Acid-Base Properties
  • Types of Side Chains
  • Henderson-Hasselbalch Equation
  • Charge and pH
  • Isoelectric Points
  • Biochem: 2.4,3.1-3.3
1/26
Competencies Lsn 6
Proteins
  • Condensation and Hydrolysis 
  • Peptide Bond Geometry and Resonance
  • Protein Primary Structure and Disulfide Bonds
  • Secondary Structure - Alpha Helices, Beta Sheets
  • Key Interactions for Protein Folding, Prions
  • "Protein Structure and ATP"
  • Biochem: 3.4-3.5; 4.1-4.6
  • Proteins
1/31
Competencies Lsn 7
Chemical Kinetics
  • Chemical Reaction Requirements
  • Arrhenius Model
  • Reaction Rates and Rate Law 
  • Arrhenius Equation
  • Experimental Determination of Reaction Order 
  • Rate Constants and Activation Energy
  • Arrhenius Plots
  • Kotz: 15.5
  • Biochem: 6.1-6.5
  • Kotz 15.3
2/2
Competencies Lsn 8
Enzyme Kinetics
  • Enzyme Mechanism of Action
  • Enzyme Inhibition
  • Enzyme-Substrate Interactions
  • Michaelis-Menton Kinetics
  • Lineweaver-Burke Plots
2/7
Competencies Lsn 9
Pharmacodynamics: Receptors and Drug Action
  • Noncovalent Interactions
  • Agonists and Antagonists
  • Dose-Response Curves
  • Overview of Receptor Types
  • "Introduction to Pharmacology" 
  • "Quantification of Pharmacodynamic Effects" 
2/9
Competencies Lsn 10
Pharmacokinetics:Absorption,Distribution,Elimination
  • Routes of Administration
  • Membrane Solubility
  • Effects of pH 
  • Half-lives and Removal Rates
  • "Introduction to Pharmacology"
  • "Pharmacokinetics I"
  • "Lipid Diffusion" from "Diffusion and Transport across Cell Membranes"
  • "Pharmacokinetics II"
2/14
Competencies Lsn 11
Nonsteroidal Anti-Inflammatory Drugs (NSAID's)
  • Arachidonic Acid Initiated Inflammation
  • Mechanism of Action for COX Inhibitors
  • Structure of Nonspecific COX Inhibitors
2/16
Competencies Lsn 12
COX-2 Inhibitors
  • Rationale for COX-2 Development
  • Molecular Design
  • Mechanism of Action
  • Therapeutic Utility and Side Effects
2/21
Test #1
2/23
Competencies Lsn 14
Central Dogma and Complex Ions
  • DNA Structure
  • Codons and RNA
  • Ligands, Metal Ions, and Complexes
  • Kotz: 22.3-22.6
  • Biochem: 9.1-9.3, 12.2
2/28
Competencies Lsn 15
Steroids
  • Steroid Structures and Properties
  • Roles as Hormones
  • Biochem: pp189-191, 24.3
  • Steroid Handout
3/2
Competencies Lsn 16
Inflammation, Steroids, and Zinc Fingers
  • Steroidal Anti-Inflammatory Mechanism of Action
  • Zinc Finger Steroid Receptors
  • "Nuclear Receptors" from "Protein Function"
  • Biochem: pp189-191, 24.3
3/7
Competencies Lsn 17
Synapse, Neurotransmitters, and Neuroreceptors
  • Neurotransmission Handout 
3/9
Competencies Lsn 18
Thermodynamics, Electrochemistry, and Neurochemistry
  • Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
  • Kotz: 19.4-19.7; 20.4-20.6
3/21
Competencies Lsn 19
Thermodynamics, Electrochemistry, and Neurochemistry
  • Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
  • Kotz: 19.4-19.7; 20.4-20.6
3/23
Competencies Lsn 20
Sodium Potassium Pump and Oxidative Phosphorylation
  • Biochem: 8.6; 20.1-20.2
  • "Active Carriers" from "Diffusion and Transport across Cell Membranes"
3/28
Competencies Lsn 21
Ion Channels
  • "Ion Channels" from "Diffusion and Transport across Cell Membranes"
3/30
Competencies Lsn 22
Neurotransmitters I
  • Neurotransmission Handout
4/4
Competencies Lsn 23
Neurotransmitters II
  • Neurotransmission Handout
4/6
Competencies Lsn 24
Chemistry of Local and General Anesthetics
  • Anesthetics and Opioid Analgesics Handout
4/11
Competencies Lsn 25
Chemistry of Opioid Analgesics
  • Anesthetics and Opioid Analgesics Handout
4/13
Competencies Lsn 26
Adrenergic Neurotransmitters and Receptors
  • Neurotransmission Handout
4/18
Test 2
4/20
Review