Date
(Competencies)
|
Topic
|
Readings
|
1/10
Competencies
Lsn 1
|
General
Chemistry I Review
-
Electronegativity &
Coulomb’s Law
-
Intermolecular Forces
-
Solubility
-
Hydrophobic/Hydrophilic
Substances
-
Vapor Pressure
-
Kinetic Energy Molecular
Distribution
|
|
1/12
Competencies
Lsn 2
|
General
Chemistry I Review
-
Molecular Geometry
-
Hybridization
-
Double Bond Geometry
-
Aromatic Electronic Structure
-
Fatty Acids, Amino Acids,
Alkaloids, Glycerol
|
-
Kotz: 10.2,11.3-11.4,pp
531-532
|
1/17
Competencies
Lsn 3
|
Condensation
and Hydrolysis Reactions
-
Reaction between Alcohols
and Carboxylic Acids
-
Triglyceride Formation
-
Peptide Formation and Hydrolysis
-
Polyphosphate Formation
|
|
1/19
Competencies
Lsn 4
|
Phospholipids
and Membranes
-
Phospholipid Formation and
Structure
-
Surfactants and Soaps
-
Membrane Structure and Properties
|
|
1/24
Competencies
Lsn 5
|
Amino Acids
and their Acid-Base Properties
-
Types of Side Chains
-
Henderson-Hasselbalch Equation
-
Charge and pH
-
Isoelectric Points
|
|
1/26
Competencies
Lsn 6
|
Proteins
-
Condensation and Hydrolysis
-
Peptide Bond Geometry and
Resonance
-
Protein Primary Structure
and Disulfide Bonds
-
Secondary Structure - Alpha
Helices, Beta Sheets
-
Key Interactions for Protein
Folding, Prions
|
-
"Protein Structure and ATP"
-
Biochem: 3.4-3.5; 4.1-4.6
-
Proteins
|
1/31
Competencies
Lsn 7
|
Chemical
Kinetics
-
Chemical Reaction Requirements
-
Arrhenius Model
-
Reaction Rates and Rate
Law
-
Arrhenius Equation
-
Experimental Determination
of Reaction Order
-
Rate Constants and Activation
Energy
-
Arrhenius Plots
|
-
Kotz: 15.5
-
Biochem: 6.1-6.5
-
Kotz 15.3
|
2/2
Competencies
Lsn 8
|
Enzyme
Kinetics
-
Enzyme Mechanism of Action
-
Enzyme Inhibition
-
Enzyme-Substrate Interactions
-
Michaelis-Menton Kinetics
-
Lineweaver-Burke Plots
|
|
2/7
Competencies
Lsn 9
|
Pharmacodynamics:
Receptors and Drug Action
-
Noncovalent Interactions
-
Agonists and Antagonists
-
Dose-Response Curves
-
Overview of Receptor Types
|
-
"Introduction to Pharmacology"
-
"Quantification of Pharmacodynamic
Effects"
|
2/9
Competencies
Lsn 10
|
Pharmacokinetics:Absorption,Distribution,Elimination
-
Routes of Administration
-
Membrane Solubility
-
Effects of pH
-
Half-lives and Removal Rates
|
-
"Introduction to Pharmacology"
-
"Pharmacokinetics I"
-
"Lipid Diffusion" from "Diffusion
and Transport across Cell Membranes"
-
"Pharmacokinetics II"
|
2/14
Competencies
Lsn 11
|
Nonsteroidal
Anti-Inflammatory Drugs (NSAID's)
-
Arachidonic Acid Initiated
Inflammation
-
Mechanism of Action for
COX Inhibitors
-
Structure of Nonspecific
COX Inhibitors
|
|
2/16
Competencies
Lsn 12
|
COX-2 Inhibitors
-
Rationale for COX-2 Development
-
Molecular Design
-
Mechanism of Action
-
Therapeutic Utility and
Side Effects
|
|
2/21
|
Test #1
|
|
2/23
Competencies
Lsn 14
|
Central
Dogma and Complex Ions
-
DNA Structure
-
Codons and RNA
-
Ligands, Metal Ions, and
Complexes
|
-
Kotz: 22.3-22.6
-
Biochem: 9.1-9.3, 12.2
|
2/28
Competencies
Lsn 15
|
Steroids
-
Steroid Structures and Properties
-
Roles as Hormones
|
-
Biochem: pp189-191, 24.3
-
Steroid Handout
|
|
3/2
Competencies
Lsn 16
|
Inflammation,
Steroids, and Zinc Fingers
-
Steroidal Anti-Inflammatory
Mechanism of Action
-
Zinc Finger Steroid Receptors
|
-
"Nuclear Receptors" from
"Protein Function"
-
Biochem: pp189-191, 24.3
|
3/7
Competencies
Lsn 17
|
Synapse,
Neurotransmitters, and Neuroreceptors
|
-
Neurotransmission Handout
|
3/9
Competencies
Lsn 18
|
Thermodynamics,
Electrochemistry, and Neurochemistry
|
-
Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
-
Kotz: 19.4-19.7; 20.4-20.6
|
3/21
Competencies
Lsn 19
|
Thermodynamics,
Electrochemistry, and Neurochemistry
|
-
Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
-
Kotz: 19.4-19.7; 20.4-20.6
|
3/23
Competencies
Lsn 20
|
Sodium
Potassium Pump and Oxidative Phosphorylation
|
-
Biochem: 8.6; 20.1-20.2
-
"Active Carriers" from "Diffusion
and Transport across Cell Membranes"
|
3/28
Competencies
Lsn 21
|
Ion Channels
|
-
"Ion Channels" from "Diffusion
and Transport across Cell Membranes"
|
3/30
Competencies
Lsn 22
|
Neurotransmitters
I
|
-
Neurotransmission Handout
|
4/4
Competencies
Lsn 23
|
Neurotransmitters
II
|
-
Neurotransmission Handout
|
4/6
Competencies
Lsn 24
|
Chemistry
of Local and General Anesthetics
|
-
Anesthetics and Opioid
Analgesics Handout
|
4/11
Competencies
Lsn 25
|
Chemistry
of Opioid Analgesics
|
-
Anesthetics and Opioid
Analgesics Handout
|
4/13
Competencies
Lsn 26
|
Adrenergic
Neurotransmitters and Receptors
|
-
Neurotransmission Handout
|
4/18
|
Test 2
|
|
4/20
|
Review
|
|