General Chemistry II Course
Competencies
Lesson 12: COX-2 Inhibitors
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Understand key differences between COX-1 and COX-2 enzymes, their physiological
roles, and their respective inhibitors
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Clearly describe the rationale for the development of COX-2 inhibitors
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Explain the structure differences between nonspecific COX inhibitors and
COX-2 specific inhibitors; relate these differences to active site geometries
of thee two enzymes
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Use COX-1 and COX-2 IC50 values for various substances to evaluate their
respective potential for therapeutic development