General Chemistry II Course
Competencies
Lesson 11: Nonsteroidal Anti-inflammatory Drugs (NSAID's)
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Understand the inflammation mechanism of action initiated by arachidonic
acid (phospholipid release of arachidonic acid, generation of prostaglandins
and thromboxanes through cyclooxygenase pathway, generation of leukotrienes
through lipoxygenase mechanism)
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Understand the mechanism of action of cyclooxygenase (COX) inhibitors
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Identify key structural features of NSAIDs and understand of specific important
interactions with COX enzymes
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Understand the specific interaction between the NSAID carboxylic group
and the COX Arg-120 side chain; describe and effectively explain the effect
upon Km values that occur when neutral glutamine is substituted
for Arg-120
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Understand and clearly discuss aspirin's unique mechanism of action for
irreversible COX inhibition