• 1/13 Instrument Calibration I: 1st Order Calibration Curves

    • Miller & Miller: Sections 5.1-5.6, Homework: Chap 5 Exercises 2,3,4

    • Calibration graphs in instrumental analysis

    • Product-moment correlation coefficient

    • Regression of y on x

    • Calculation of concentration and its random error

    • Linest Excel Function (Harris Section 4.7)

    • Problem Set 1: "Cadmium Calibration Problem"

  • 1/20 Instrument Calibration II: ANOVA, Regression Calculations, Curvilinear Regression Methods

    • Miller & Miller: Sections 5.12-5.14, Homework: Chap 5 Exercises 9,11

    • Variance, Sum of Squares (SS), and Degrees of Freedom (DOF)

    • Total Sum Squares (SStot), Regression SS (SSregr), Residual SS (SSres), and Coefficient of Determination (R2)

    • Replicate Sum of Squares (SSrepl) and Lack of Fit Sum of Squares (SSlof)

    • Curvilinear regression methods

    • Calculation of unknown concentrations from nonlinear curves (Harris Box 4-2)

    • Problem Set 2: "Sum of Squares Calculation," Sum of Squares Classroom Handout

  • 1/27 Instrument Calibration III: Limits of  Detection, the Method of Standard Addition Class Example

    • Miller & Miller: Sections 5.7-5.8, Homework: Chap 5 Exercises 5,6,7

    • Limits of detection

    • Method of standard additions

    • Problem Set 3

  • 2/3 Instrument Calibration IV: Internal Standard Methods of Quantitation Class Example

    • Internal standard (IS) methodology (Harris 5-4)

    • Response factor IS methods

    • Response ratio IS methods

    • Problem Set 4

  • 2/10 Descriptive Statistics I: Sec 2.1-2.6

    • Mean and standard deviation

    • Distribution of repeated measurements

    • Log-normal distribution

    • Sample definition and sampling distribution of the mean

    • Confidence limits of the mean for large samples

  • 2/17 Calibration Quiz

  • 2/24 Descriptive Statistics II: Sec 2.7-2.12

    • Homework: Chap 2 Exercises 3,4,5,8,

    • Confidence limits of the mean for small samples

    • Presentation of results and uses of confidence limits

    • Confidence limits of a log-normal distribution

    • Propagation of error

  • 3/3 Inferential Statistics: Sec 3.1-3.6,

    • Homework: Chap 3 Exercises 1,2,3,4,6

    • Homework: Problem Set 5, Data Set 1 Download

    • Comparison of experimental mean with known value

    • Comparison of two experimental means

    • Paired t-test

    • One-sided and two-sided tests

    • F-Test for the comparison of standard deviations

    • Outliers

  • 3/10 No Class

  • 3/24 Analysis of Variance: Sec 3.8-3.10, 7.1-7.5

    • Homework: Chap 3 Exercises 5,7,9,11

    • Analysis of variance (ANOVA)

    • The arithmetic of ANOVA calculations

    • Two-way ANOVA

    • Two-way ANOVA with interaction

  • 3/31 Analytical Quality I: Sec 4.1-4.7C

    • Sampling

    • Separation and estimation of variances using ANOVA

    • Sampling strategy

    • Quality control methods

    • Shewhart control charts for mean values and ranges

    • PS 6: Miller 3.4, 3.6, 3.11, 3.13, 7.2, 7.5 (for 3.11 & 7.2, also manually calculate in spreadsheet SS, MSS, F’s)

  • 4/7 Analytical Quality II: Sec 4.8-4.13

    • Sampling and Control Chart Problem Set 7 Due Data Set

    • Establishing process limits and capability

    • Average run lengths and cumulative sum charts

    • Proficiency testing schemes

    • Collaborative trials

    • Uncertainty

  • 4/14 TBA

  • 4/21 TBA

  • 4/27 Cumulative Final Examination 11:30 AM