Date

  Lesson

1/15

  1. Gen Chem I Review: Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure

Text Assignment: GenChem - all applicable chapters;  MedChem - Chapter 2

 

1/17

PS1

Due!

  1. Gen Chem I Review - Intermolecular Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions

Text Assignment: GenChem - applicable chapters;  MedChem - Chapter 2

 

1/22

  1. Solubility: Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties

Text Assignment: MedChem – Chapter 2, also pp:273-275 (partition coefficient p)

Link: UCSF Membrane Tutorial (Great resource!!)

 

1/24

PS2

Due!

  1. Condensation and Hydrolysis Reactions: Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation

Text Assignment: MedChem – Chapter 2

Handout: Condensation and Hydrolysis Reactions

 

1/29

PS3

Due!

  1. Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and Hydrolysis

Text Assignment: MedChem – Chapter 3 and Appendix 1

 

1/31

PS4 Due!

  1. Acid-Base Properties of Amino Acids: Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH

Text Assignment: GenChem - applicable chapters;  MedChem - Chapter 3

UCSF Reading: “Diffusion and Transport Across Membranes” (Great resource!!)

 

2/5

PS5

Due!

  1. Protein Structure: Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications

Text Assignment: MedChem – Chapter 3

 

2/7

  1. Chemical Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular Distribution

Text Assignment: GenChem - applicable chapters

 

2/12

PS6 Due!

  1. Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate Binding, Enzyme Inhibition, Competitive and Allosteric Inhibitors

Text Assignment: GenChem - applicable chapters, MedChem – Chapter 4

 

2/14

  1. Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity

Text Assignment: MedChem – Chapter 4

 

2/19

  1. Mid-Term Exam: Some problems for practice…

 

2/21

 

  1. Receptors as Drug Targets I: Neurotransmitters and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists, Sensitization, Tolerance, and Dependence

Text Assignment: MedChem – Chapter 5

 

2/26

PS7 Due

  1. Receptors as Drug Targets II: Affinity, Efficacy, and Potency; Dissociation Binding Equilibria, EC50, IC 50, and Scatchard Plots

Text Assignment: MedChem – Chapter 5

 

2/28

PS8 Due

  1. Receptor Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal) Receptors

Text Assignment: MedChem – Chapter 6

 

3/4

  1. Ion Channels and Thermodynamics I: Ion Concentration Gradients, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes

Text Assignment: MedChem – Chapter 6

UCSF Reading: “Diffusion and Transport Across Membranes” (pp73-77: ATP ion pumps, pp80-84: Ion channels)

 

3/6

  1. Ion Channels and Thermodynamics II: Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes

Text Assignment: MedChem – Chapter 6

UCSF Reading: “Diffusion and Transport Across Membranes” (pp73-77: ATP ion pumps, pp80-84: Ion channels)

 

3/11

PS9

Due

  1. Receptor Structure and Signal Transduction II:

GPCR's: G-Protein Coupled Receptors Signaling Mechanism of Action

Text Assignment: MedChem – Chapter 6

 

3/13

  1. Receptor Structure and Signal Transduction III

Steroids and Intracellular Steroidal Receptors: Steroid Structure and Hydrophobicity, Complex Ions and Zinc Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment of Hormone-Dependent Breast Cancers

Text Assignment: MedChem – Chapter 6

 

3/25

  1. Cholinergics I 

Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding

Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action  of nerves)

 

3/27

  1. Cholinergics II

Cholinergic Antagonists, Acetylcholinesterase Inhibitors

Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action  of nerves)

 

4/1

  1. Adrenergics

Geometry of adrenergic receptors, main types of norepinephrine receptors, interaction of adrenergic receptors with neurotransmitters, MOA of activated receptors

Text Assignment: MedChem – Chapter 20

 

4/3

  1. Psychoactive Drugs I: Stimulants

Handout:

 

4/8

  1. Psychoactive Drugs II: Anti-Depressants

Handout:

 

4/10

  1. Psychoactive Drugs III: Hallucinogens

Handout:

 

4/15

  1. Opium and Opioid Analgesics

Source and history of opiates, structure of opioids and opioid receptors,  endogenous opioids, side effects of opiates

Text Assignment: MedChem – Chapter 21

 

4/17

  1. Chemistry of Local & General Anesthetics

MOA for local anesthetics, pKa relevance, history of cocaine use by humans, MOA for general anesthetics, molecular structures of widely used general anesthetics

Handout:  Local and General Anesthetics

 

4/22

  1. Test 2

 

4/24

  1. Review

 

5/1

  1. Final Cumulative Exam: Thursday, May 1 beginning at 11:30 AM