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CONTACT INFORMATION
Dr. Jason C. Hurlbert
301B Sims Science Bldg
Rock Hill, SC 29733, USA
803/323-4928
803/323-2246 (fax)

CHEM523: Biochemistry I (Spring 2014)

Detailed Schedule:

This page contains specific links to lectures, documents and assignments. Optional reading assignments (scientific papers, etc) will be linked to on this page. The homework assignments in the "Assignment Due" column are due at the start of class on the day indicated, WITHOUT exception.

Please Note: Audio and Lecture files are copyrighted materials and may not be used for anything other than CHEM523 without my express written permission.

Week Date Topic Assignment Due
1

13 Jan

Lecture 1

Audio recording of Lecture 1

Course Introduction

Chapter 1: The Foundations of Biochemistry

1.1: Cellular Foundations

1.2: Chemical Foundations

1.3: Physical Foundations

1.4: Genetic Foundations

1.5: Evolutionary Foundations

Show up to class ready to get to work!

15 Jan

No Class Meeting Today!

17 Jan

Lecture 2

Audio recording of Lecture 2

Chapter 2: Water

2.1: Weak Interactions in Aqueous SYstems

2.2: Ionization of Water, Weak Acids and Weak Bases

2.3: Buffering against pH Changes in Biological Systems

2.4: Water as a Reactant

2.5: The Fitness of the Aqueous Environment for Living Organisms

HW1: Chapter 1 Problems 2, 7, 9, 16 Crossword 1

2

20 Jan

Martin Luther King, Jr. Holiday

No Scheduled Meeting

22 Jan

Lecture 3

Chapter 3: Amino Acids, Peptides and Proteins

3.1: Amino Acids

3.2: Peptides and Proteins

HW2 Syllabus and Website homework, Chapter 2 Problems 1, 2, 4, 9, 16, 20, 27, 28, 31, 35, Crossword 2

24 Jan

Audio recording of Lecture 3 Part 2

3.3: Working with Proteins

3.4: The Structure of Proteins: Primary Structure

 
3

27 Jan

Lecture 4

Audio recording of Lecture 4 Part 1

 

Chapter 4: The 3D Structure of Proteins

4.1: Overview of Protein Structure

4.2: Protein Secondary Structure

HW3 Chapter 3 Problems 2, 7, 8, 9, 11, 15, 18, 21, 22, Crossword 3

29 Jan

Audio recording of Lecture 4 Part 2

Chapter 4: The 3D Structure of Proteins

4.3: Protein Tertiary and Quaternary Structures

4.4: Protein Denaturation and Folding

 

31 Jan

Lecture 3a

Lecture 4a

Using NCBI/Entrez

An introduction to the PDB and PDB Files

HW4 Chapter 4 Problems 1, 4, 7, 10, 15, 16, Crossword 4

4

3 Feb

Lecture 5

Chapter 5: Protein Function

5.1: Reversible Binding of a Protein to a Ligand: Oxygen-binding Proteins

 

5 Feb

Lecture 6

Chapter 6: Enzymes

6.1: An Introduction to Enzymes

6.2: How Enzymes Work

6.3: Enzyme Kinetics as an Approach to Understanding Mechanism

HW5 Chapter 5 Problems1, 2, 8, 15

7 Feb

  PDB Assignment Due
5

10 Feb

Lecture 7

Chapter 6: Enzymes

6.4: Examples of Enzymatic Mechanisms

 

12 Feb

  Chimera Assignment Due

14 Feb

Lecture 8

6.5: Regulation of Enzymatic Activty
HW6 Chapter 6: 4, 5, 6, 8, 9, 10, 11, 16,19, 21, 22, 23, Crossword 6
6

17 Feb

Test 1

19 Feb

Lecture 9

Chapter 7: Carbohydrates and Glycobiology

7.1: Monosaccharides and Disaccharides

7.2: Polysaccharides

7.3: Glycoconjugates: Proteoglycans, Glycoproteins and Glycosphingolipids

7.4: Carbohydrates as Informational Molecules: The Sugar Code

 

21 Feb

   
7

24 Feb

Lecture 11

Chapter 8: Nucleotides and Nucleic Acids

8.1: Some Basics

8.2: Mucleic Acid Structure

8.3: Nucleic Acid Chemistry

8.4: Other Functions of Nucleotides

HW 7: Chapter 7 Problems 2, 7, 15, 17, 20, 27, Crossword 7

26 Feb

Lecture 12

 

Chapter 10: Lipids

10.1: Storage Lipids

10.2: Structural Lipids in Membranes

10.3: Lipids as Signals, Cofactors and Pigments

HW8: Chapter 8 Problems 1, 2, 10, 11, 14, 18, Crossword 8

28 Feb

Lecture 13

Chapter 11: Biological Membranes

11.1: The Compositon and Architecture of Membranes

11.2: Membrane Dynamics

11.3: Solute Transport Across Membranes

HW9: Chapter 10 Problems 2, 9, 12, 14, Crossword 10
8

3 Mar

   

5 Mar

Lecture 14

Chapter 12: Biosignaling

12.1: General Features of Signal Transduction

12.2: G-Protein Coupled Receptors and Second Messengers

HW10: Chapter 11 Problems 4, 6, 24, 25, Crossword 11

7 Mar

Lecture 15

 

Chapter 12: Biosignaling

12.3: Receptor Tyrosine Kinases

12.11: Regulation of Cell Cycle by Protein Kinases

Movie of INSR Activation

 
9

10 Mar

Review for Exam HW11: Chapter 12 Problems 3, 10, 13

12 Mar

Review for Exam

 
14 Mar

Test 2

10 17 Mar - 21 Mar
Spring Break
11

24 Mar

Lecture 17

Chapter 24: Genes and Chromosomes

Supplemental Article:

John Nitiss. (2009). Targeting DNA topoisomerase II in cancer chemotherapy. Nature Cancer Reviews 9: 338–350.

 

26 Mar

Lecture 18

Chapter 25: DNA Metabolism

25.1: DNA Replication

 
28 Mar   HW12: Chapter 24 Problems 4, 6, 14, 15, Crossword 24

 

12

 

31 Mar

Lecture 19

Chapter 26: RNA Metabolism

26.1: DNA-dependent Synthesis of RNA

 

2 Apr    

4 Apr

Biological Redox Reactions

HW13: Chapter 25 Problems 1, 8, 9, 10, 11

 

13

 

7 Apr

Lecture 20

Chapter 27: Protein Metabolism

27.1: The Genetic Code

27.2: Protein Synthesis

 

9 Apr

Test 3 Review  
11 Apr Test 3 Review HW14: Chapter 26 Problems 5, 11, 12, Crossword 26

14

14 Apr

Test 3
16 Apr Presentation Review
18 Apr Presentation Review

15

21 Apr

Rosa Razo

Nick Miller

Derion Reid

Charles Nelson

23 Apr

Montana Houssard

Lucas Boncorddo

Grace Jones

Jamie Murakami

25 Apr

Lukas Ballard

Sarah Wicks

Stephanie Henry

Matthew Raad

16 Monday, 28 Apr @ 9:00AM Final Paper Due in Dropbox Folder
 
Final Exam: Tuesday, 6 May at 11:30 AM in Sims 113C