CHEM520: Essentials of Biochemistry

Instructor: Dr. Takita F. Sumter (sumtert at winthrop.edu)

Course Meeting Time: TR 8:00-9:15am, Sims 105 Office hours: TBA and by appt Office: Sims 302C


Course Goals: CHEM 520 provides an in depth study of the structure, chemistry, macromolecular interactions of biochemical systems. To that end, the course covers the synthesis and metabolism of major macromolecules using an applied approach enzyme kinetics and mechanisms, thermodynamics of biological processes, and the basic principles of relevant techniques used in biochemistry and molecular biology. These goals enable students to think critically and solve problems (ULC #1) while also providing them the skills needed to understand the interconnected nature of the world and time in which they live (ULC #4).


Student Learning Outcomes: In accordance with the goals of the ACS/ASBMB Accredited Biochemistry Program, students will demonstrate the following skills upon course completion:

to discuss your rationale with classmates so that you will be able to clearly and logically communicate your reasoning on an exam.


o Additional Requirements for Graduate Credit: Students receiving graduate credit (both non- degree seeking and those working toward a degree) will be required to complete a 5-7 page paper on a controversial topic related to biochemistry. A proposal describing the topic, its relevance to this course, and the controversy must be submitted by March 8, 2019. This paper must cite at least

7 primary literature sources and must be submitted by April 12, 2019. A 20 minute oral presentation of your paper will be scheduled and presented to the class. The paper and presentation are each worth 50 points to give the course total for graduate students 1100.


Grading: Final grades will be assigned using the Plus/Minus grading system. Your grade will be based on the total points that you earn as follows: 920-1000 = A, 860-919 = B+, 800-859 = B, 760-799 = C+, 700-759 = C, 660-699 = D+, 600-659 = D, 599 or less = F


Academic Misconduct: Winthrop has a strict Student Conduct Code printed in the Winthrop University Student Handbook. Read it carefully and avoid any infractions such as cheating or plagiarism.


Students with Disabilities: Winthrop University is committed to providing access to education. If you have a condition which may adversely impact your ability to access academics and/or campus life, and you require specific accommodations to complete this course, contact the Office of Disability Services (ODS) at 803-323- 3290, or, accessibility@winthrop.edu. An official notice of accommodations from the Office of Disability Services must be submitted at least one week prior to the first exam.


Student Responsibility: This is a rigorous upper level course. Average students should spend at least 9 hours per week preparing. Suggestions for preparation:

Spring 2019 Lecture and Course Preparation Schedule (TR)

Date

Day

Topic

Reading

8-Jan

T

Proteins

Ch. 3

10-Jan

R

Protein Structure

Ch. 3

15-Jan

T

Enzymes Ch. 7

17-Jan

R

Carbohydrates

Ch. 6

22-Jan

T

Cont'd

24-Jan

R

Glycolysis-Energy Generation

Ch. 8

29-Jan

T

Regulation of Glycolosis

31-Jan

R

cont'd

5-Feb

T

EXAM I

7-Feb

R

TCA

Ch. 9

12-Feb

T

Electron Transport

Ch. 9

14-Feb

R

cont'd

19-Feb

T

cont'd

21-Feb

R

Glycogenolysis

Ch. 11

26-Feb

T

Gluconeogenesis

28-Feb

R

cont'd

Ch. 11

5-Mar

T

Presentations

7-Mar

R

EXAM II

12-Mar

T

SPRING BREAK

14-Mar

R

SPRING BREAK

19-Mar

T

Lipids and Membranes

Ch. 5

21-Mar

R

cont'd

26-Mar

T

Membrane structure

28-Mar

R

Lipid Metabolism

Ch. 12

2-Apr

T

Amino Acid Biosynthesis/Amino Acid Metabolism Project Due

4-Apr

R

Nitrogen Metabolism

Ch. 13

9-Apr

T

cont'd

11-Apr

R

Experimental Tools to Understand Macromolecule

Ch. 18/19

16-Apr

T

cont'd

cont'd

18-Apr

R

Stuent Presentations

27-Apr

ST

Final Exam--8:00 AM