Principal Investigator/Program Director (Last, First, Middle): |
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BIOGRAPHICAL SKETCHProvide the following information for the key personnel
and other significant contributors in the order listed on Form Page 2. |
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NAME Chasta L. Parker |
POSITION TITLE Associate
Professor of Chemistry |
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eRA COMMONS USER NAME |
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EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) |
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INSTITUTION AND LOCATION |
DEGREE (if
applicable) |
YEAR(s) |
FIELD OF STUDY |
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B.S. |
1992 – 96 |
Chemistry |
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Ph.D. |
1996 – 01 |
Biochemistry |
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A. Positions
and Honors.
Positions
1996 – 2001 Graduate Research Assistant,
2001 – 2007 Assistant Professor of Chemistry,
2007 – Present Associate Professor of Chemistry,
Professional Memberships
1996 – present Member, American Chemical Society
1997 – present Member, Sigma Xi Scientific Research Society
1997 – 1998 President, Society for the Advancement of Chemical Sciences
2001 – present Member, Council on Undergraduate Research
2001 – present Member, South Carolina Academy of Sciences
2004 – present Member, American Society for Biochemistry and Molecular Biology
2006 – present Member, American Association for the Advancement of Science
2007 – 2008 Councillor,
2008 – present Secretary, South Carolina Academy of Sciences
Honors
1998 Joseph W. Bouknight
Graduate Teaching Award,
1998 Distinguished Teaching Assistantship,
2003 Presidential Citation in
Recognition for Earning a competitive research grant,
2005 2005 American Society for Biochemistry and Molecular Biology
Undergraduate Faculty Travel Award to annual meeting in
2005 Presidential Citation in
Recognition for Acting as
2006 2006 American Society for Biochemistry and Molecular Biology
Undergraduate Faculty Travel Award to annual meeting in
2006 Presidential Citation in
Recognition for Earning the NIH-INBRE grant,
2007 Elected to a council position for the South Carolina Academy of Sciences.
2007 Awarded Tenure and
promotion at
2008 Elected Secretary for the
Courses Taught
Chem 105 General
Chemistry I
Chem 107 General
Chemistry Laboratory I
Chem 108 General
Chemistry Laboratory II
Chem 351 Independent
Study
Chem 521 Nutritional
Biochemistry
Chem 523 Biochemistry
I
Chem 524 Biochemistry
II
Chem 525 Biochemical
Techniques Laboratory
Chem 551/552 Research
I and II
Biol 471/472 Undergraduate
Research in Biology
Hmxp 102 The
Human Experience: Who Am I?
B.
Peer-reviewed Publications and
Presentations
Publications
1. Schreck, S.F., Parker, C., Plumb, M.E. and Sodetz, J.M. (2000) Human Complement Component C8g. Biochim. Biophys. Acta 1482, 199-208.
2. Ortlund, E., Parker, C., Schreck, S.F., Sodetz, J.M. and Lebioda, L. (2002) Crystal Structure of Human Complement Protein C8g at 1.2Å Resolution Reveals a Lipocalin-like Fold and a Distinct Ligand Binding Site. Biochemistry. 41(22), 7030-7037.
3. Parker, C. and Sodetz, J.M. (2002) Role of the Human C8 Subunits in Complement-Mediated Bacterial Killing: Evidence that C8g is not Essential. Mol. Immunol. 39(7-8), 453-458.
4. Parker, C. (2007) Focus on Our Future: Student Zainab Ghadiyali. Enzymatic 4(3), 8-10.
Presentations (bold indicates undergraduate
student)
1.
Schreck,
S.F., Parker, C., Lebioda, L. and Sodetz, J.M. (1998) “Production and
Characterization of Recombinant Human Complement Component C8g,”. Bull. S.C. Acad. Sci. 60, 106.
Presented as a poster.
2.
Schreck,
S.F., Parker, C., Lebioda, L. and Sodetz, J.M.
(1998) “Production and Characterization of Recombinant Human Complement
Component C8g”, FASEB J. 12,
A293. Presented as a talk at ASBMB meeting.
3.
Ortlund,
E., Parker, C., Schreck, S.F., Minor, W., Sodetz, J.M., and Lebioda, L. (2001)
“Three
Dimensional X-ray Crystal
Structure of Human Complement Protein C8 Gamma at 1.2A
Resolution”, Tenth
4.
Parker,
C., Ortlund, E., Schreck, S.F., Lebioda, L. and Sodetz, J.M. (2001) “Human Complement
Component C8:
Structure-Function Analysis of the C8g Subunit”, Bull. S.C. Acad. Sci. 74, 94. SCAS,
5.
Ortlund,
E., Parker, C., Schreck, S.F., Minor, W., Sodetz, J.M., and Lebioda, L.
(2001) “Three
Dimensional Crystal
Structure of Human Complement Protein C8 Gamma at 1.2 A Resolution
Suggests a Mechanism for
Signaling Between the C8 Alpha and C8 Gamma Subunits”, Mid-
Atlantic Crystallography
Conference,
6. Sodetz,
J.M., Ortlund, E., Parker, C.L., Schreck, S.F., and Lebioda, L. (2002)
“The Crystal Structure of Human Complement Protein C8g Provides New Insight into its
Function.” XIX International Complement
Workshop,
7. Sodetz,
J.M., Ortlund, E., Parker, C.L., and Lebioda, L. (2003) Human Complement
Protein C8g: The Sole Lipocalin in the Complement
System. International Lipocalin Meeting,
8. Bork, D., Murphy, K., Chiswell, B., Sodetz,
J.M., and Parker, C.L. (2003) “Production of a Recombinant C8a Protein Fragment for Structural
Analysis.” Bull. S.C. Acad. Sci. 76, 61. SCAS meeting at
9.
Rai, N., Bork, D., Murphy, K.,
Dimond, E.,
Chiswell, B., Sodetz, J.M., and Parker, C.L. (2003) “Production of a
Recombinant C8a Protein Fragment for Structural Analysis.” Poster presentation at
10. Dimond, E., Bork, D., Murphy, K, Rai, N.,
Chiswell, B., Sodetz, J.M., and Parker, C.L. (2003) “Production of a Recombinant C8a Protein
Fragment for Structural Analysis.” 55th
Southeast Regional Meeting of the American Chemical Society. presented as a
poster.
11. Walker, L., and Parker, C. (2005)
“Expression and Purification of Recombinant AdipoR1 in Sf9 cells” Poster
Presentation. 19th National Conference on Undergraduate Research.
12. Fowlkes, V., and Parker, C. (2005) “Reproduction of
Recombinant MACPF C8alpha in Sf9 Insect Cells” Oral Presentation. 19th
National Conference on Undergraduate Research.
13. Parker
C., Bork, D., Dimond, E., Rai, N.,
Murphy, K., Chiswell, B., and Sodetz, J. (2004) “Production of a recombinant
membrane-binding region of C8α for structural analysis.” A81.6. Presented as a poster at ASBMB in
14. Walker, L.,
and Parker, C. (2005) “Expression and
Purification of AdipoR1 in Sf9 cells.” FASEB
J. 19(5), A234.1. Presented as a
Poster at ASBMB meeting in
15. Fowlkes, V.,
and Parker, C. (2005) “Cloning and Expression of C8α in Sf9 insect cells.”
FASEB J.
19(5), A234.5. Presented as a poster at ASBMB meeting in
16. Parker, C. (2005) “The Biochemistry Laboratory: Using an Integrative Approach to Teaching
Basic Biochemical Techniques.” FASEB
J. 19(5), A800.19. Presented as a
poster at ASBMB meeting in
17. Walker, L., and Parker, C. (2005)
“Expression and Purification of Recombinant AdipoR1 in Sf9 cells.” Bull. S.C. Acad. Sci. Volume LXVII. SCAS meeting at
18. Parker,
C. (2006) “The Biochemistry Laboratory:
Using an Integrative Approach to Engage Students in Deep Learning.” FASEB J.
20(5), A975. Presented as a poster at ASBMB meeting in
19. Ghadiyali, Z., and Parker, C. (2006)
“Production of the MACPF Region of Complement C8alpha in Sf9 Insect
Cells.” FASEB J. 20(4), A462 – A463. Presented as a poster at ASBMB meeting
in
20. Ghadiyali, Z., and Parker, C. (2006)
“Production of Recombinant MACPF Complement C8α in Sf9 Insect Cells for
Protein Production and Purification.” Presented as a poster at the National
Conference on Undergraduate Research in
1. Glazener, R., and Parker, C. (2006) “Kinetic
Characterization of Arylamine N-Acetyltransferase 2 Using the Substrate
Sulfamethazine.” Presented as a poster at the 1st Annual South
Carolina Chemistry Colloquium in
2. Kissinger, S., and Parker, C. (2006)
“Expression of Adiponectin Receptor 1 in Sf9 Cells.” Presented as a poster at
the 1st Annual South Carolina Chemistry Colloquium in Columbia,
SC October 7.
3. Ghadiyali, Z.,
and Parker, C. (2006) “Expression and purification of Human Adiponectin
receptor, AdipoR2 in Sf-9 Insect for Structural Analysis and Biochemical
Assays.” Presented as a talk at the Southeast Regional Meeting of the National
Organization of Black Chemists and Chemical Engineers, Augusta, GA. November 10
-11.
4. Baker, I., and Parker, C. (2006) “Cloning,
Expression and Purification of Arylamine N-Acetyltransferase 2” Presented as a
poster at the Southeast Regional Meeting of the National Organization of Black
Chemists and Chemical Engineers, Augusta, GA. November 10 -11.
5. Parker,
C., Ghadiyali, Z., Kissinger, S.,
6. Glazener, R., Baker, I., Hurlbert, J, and Parker,
C. (2007) “Kinetic characterization of Arylamine N-Acetyltransferase 2 using
the substrates sulfamethazine and 5-aminosalicylic acid” National Meeting of
the American Chemical Society,
7. Baker, I., and Parker, C. (2007)
“Expression and Purification of Human Arylamine N-Acetyltransferase 2” National
Meeting of the American Chemical Society,
8. Ghadiyali, Z., and Parker, C. (2007) “Cloning,
Expression and Purification of Human Adiponectin Receptor, AdipoR2” National
Meeting of the American Chemical Society,
9. Kissinger, S., Walker, L., and
Parker, C. (2007) “Expression of Adiponectin Membrane Receptor 1 in Sf9 cells”
National Meeting of the American Chemical Society, Chicago,IL, March 25-29.
10. Glazener, R., Baker,
11. Kissinger, S., Walker, L.,
Hurlbert, J. and Parker, C. (2007) “Expression of Human Adiponectin Membrane
Receptor 1 in Sf9 cells” National Conference on Undergraduate Research, CA,
April 12 – 14.
12. Ghadiyali, Z., and Parker, C. (2007) “Cloning,
Expression, and Purification of Human Adiponectin Receptor, AdipoR2 for
Structural Analysis and Biochemical Assays”
National Organization of Black Chemists and Chemical Engineers, Fl,
April 1-7.
13. Faile, K., James, A., and Parker, C. (2007)
“Expression of Adiponectin Protein Receptors: AdipoR1 and AdipoR2” USC 2nd Annual Chemistry
Coloquium,
14. James, A., Faile, K.L., and Parker, C. (2008)
"Adiponectin Membrane Receptors: ADIPOR1 and ADIPOR2" Oral presentation at the South Carolina
Academy of Sciences,
15. Faile, K., James, A., and Parker, C. (2008)
“Adiponectin Membrane Receptors 1 and 2" Poster presented at Experimental
Biology - American Association of Biochemistry and Molecular Biology, San
Diego, CA, April 4 - 8th.
16. James, A., Faile, K.L., and Parker, C. (2008)
"Adiponectin Membrane Receptors: ADIPOR1 and ADIPOR2" Oral presentation at the National Conference
on Undergraduate Research,
A. Research
Support.
Ongoing Research Support:
2 P20 RR016461-05A1 Baynes
(PI) 07/01/2005
– 04/30/2010
SC IdeA Network of Biomedical Research Excellence
The major goal at
Role: Co-PI Project Investigator for
CHE-0722722 Hurlbert
(PI) 08/15/2007
– 07/31/2010
National Science Foundation – Major Research
Instrumentation Program
This grant was awarded to provide a Voyager DE STR MALDI TOF and An
AB/Sciex API 2000 Triple Quad MS/MS instruments for research and teaching at
Role:
Co-PI
5-29183 Parker
(PI) 05/16/2007
– 06/30/2008
The major goal of this grant is to provide funds
for student summer/academic year salary.
Role: PI
Completed Research Support:
529145 Parker
(PI) 05/16/2006 –
06/30/2007
Production and Purification of Recombinant Human
Adiponectin Membrane Receptor 1 (AdipoR1) form Sf 9 insect cells
This grant funded a student co-investigator
for summer research to work on the production and purification of AdipoR1 for
structural studies.
Role: PI
529154 Parker
(PI) 05/16/2006 –
06/30/2007
Development of an Enzyme Kinetic Assay to
Measure the Rate of Reaction of Pigeon Liver N-Acetyltransferase 2 (NAT 2)
The purpose of this grant was to fund a
student co-investigator for the summer to work on adapting a useable assay for
analysis of NAT 2 activity. The grant
also supplied some money for supplies.
Role: PI
529108 Lammi (PI) 05/16/2005 – 06/30/2006
Flourescent Monitoring of Metal-Induced Conformational Change in
Amyloid Beta Peptide
The purpose of this grant was to fund an undergraduate research student
in the summer 2005 and to purchase
required supplies.
Role: Co - PI
529071 Parker
(PI) 05/16/2004 –
06/30/2005
Purification, Crystallization and Structural Analysis of the Membrane
Binding Domain of Human Complement Protein C8alpha.
This grant was used to fund an undergraduate student to work on the
project over summer 2004.
Role: PI
NSF/EPSCoR EPS-0132573 and NIH/BRIN 8-P0RR16461A Parker (PI)
10/10/2003 – 04/30/2004
Winthrop University SC-BRIN/EPSCoR Network Seminar Program
This grant is being used to fund speakers from all over
Role: PI
NSF/EPSCoR EPS-0132573 and NIH/BRIN 8-P0RR16461A Sodetz (PI)
05/15/2002 – 08/30/2003
SC-BRIN/EPSCoR
Structural Analysis of the Membrane-Binding Domain of Human Complement
Protein C8a
The goal of this project was to create cDNA clones of the MACPF region
of C8a, express it in
bacteria and attempt crystallization.
Role: Co-PI
NSF/EPSCoR EPS-0132573 and NIH/BRIN 8-P0RR16461A Sodetz (PI)
09/01/2003 – 06/30/2004
SC-BRIN/EPSCoR
Structural Analysis of the Membrane-Binding Domain of Human Complement
Protein C8a
The goal of this project was to use cDNA clones of the MACPF region of
C8a to increase expression levels in bacteria
and attempt crystallization.
Role: Co-PI
529010 Parker
(PI) 05/1/2003 – 06/30/2004
Structural Analysis of the Membrane-Binding Domain of Human Complement
Protein C8 Alpha
The purpose of this grant was to fund two undergraduate research
students in the summer 2003.
Role: PI