General Chemistry II Syllabus for the Applied Medicinal Chemistry
and Neuroscience Approach
1 |
Review: Electronegativity, Electron
Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double
Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor
Pressure |
2 |
Intermolecular
Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der
Waals Interactions, Dipole-Dipole and Ion-Dipole
Interactions, Repulsive Interactions, Water Solvation,
and Hydrophic Interactions |
3 |
Solubility: Thermodynamics of Liquid-Lquid Solubility, Octanol-Water Distribution Equilibrium Constants
[Partition Coefficients (P)], Phospholipid
Components and Structure, Cell Membrane Structure and Properties |
4 |
Condensation and
Hydrolysis Reactions:Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation |
5 |
Amino Acids: Structure, Chirality,
Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and
Hydrolysis |
6 |
Acid-Base
Properties of Amino Acids:Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH |
7 |
Protein
Structure: Primary
Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta
Sheets, Tertiary/Quaternary Structures and Associated Noncovalent
Interactions, Prions, PostTranslational
Protein Modifications |
8 |
Chemical
Kinetics:
Factors Affecting Reaction Rates, Rate Law, Arrhenius
Equation, Activation Energy, Kinetic Molecular Distribution |
9 |
Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate
Binding, Enzyme Inhibition, Competitive and Allosteric
Inhibitors |
10 |
Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax
Determination, Turnover Numbers, Km and Substate-Enzyme
Affinity |
11 |
Mid-Term Exam |
12 |
Receptors as
Drug Targets I: Neurotransmitters
and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists,
Sensitization, Tolerance, and Dependence |
13 |
Receptors as
Drug Targets II: Affinity,
Efficacy, and Potency; Dissociation Binding Equilibria,
EC50, IC 50, and Scatchard Plots |
14 |
Receptor
Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal)
Receptors |
15 |
Receptor
Structure and Signal Transduction II -
Ion Channels and Thermodynamics: Ion Concentration Gradients, Sodium-Potassium-ATP
Pump Mechanism, Cell Membrane Potentials, Nernst
Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion
Movement across Voltage and Concentration Gradients, Ion Movements and
Resulting Inhibitory/Excitatory Potential Changes |
16 |
Receptor
Structure and Signal Transduction III - GPCR's: G-Protein Coupled Receptors Signalzing
Mechanism of Action |
17 |
Receptor
Structure and Signal Transduction IV - Steroids and Intracellular Steroidal
Receptors: Steroid
Structure and Hydrophobicity, Complex Ions and Zinc
Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment
of Hormone-Dependent Breast Cancers |
18 |
Cholinergics I |
19 |
Cholinergics II |
20 |
Adrenergics I |
21 |
Adrenergics II |
22 |
Psychoactive
Drugs I: Stimulants |
23 |
Psychoactive
Drugs II: Anti-Depressants |
24 |
Psychoactive
Drugs III: Hallucinogens |
25 |
Opium and Opioid Analgesics |
26 |
Chemistry of
Local & General Anesthetics |
27 |
Test 2 |
28 |
Review |