General Chemistry II Course Competencies
Lsn 2: Intro to Drug Targets and Interactions II
(Solubility, log P Calculations, Phospholipids, Membranes)
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Solubility and hydrophilic/hydrophobic substances
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Understand the difference and be able to predict relative polarities and
solubilities (hydrophilic/hydrophobic, lipophilic/lipophobic) of a given
molecular structure
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Understand and clearly explain the basis for the structure of surfactants
and soap molecules
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Understand and describe the basis for micelle formation and action
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Understand what is meant by the octanol-water partition coefficient and
clearly describe its significance (P and log P)
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Phospholipids
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Understand the component substructures within phospholipid molecules
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Know the molecular structures of the alcohols (glycerol, serine, choline,
ethanolamine) used to make phospholipids
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Outline the chemical reactions and mechanisms for the formation of phospholipids
from molecular subcomponents
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Outline the reactions involved in phospholipid hydrolysis
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Membranes
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Understand and draw the molecular structure of membranes
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Understand and describe the forces that hold membranes together
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Clearly outline the role of cholesterol in cell membranes
Predict relative membrane permeability for a variety of types of molecules
or ions
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Fats, oils, and fatty acids
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Know the structure of saturated, monounsaturated, polyunsaturated, and
trans fats; describe associated health effects
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Understand cis- and trans-geometry and the formation of trans-fats
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Relate the melting points of fats and oils to molecular structure
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Understand olestra’s synthesis, structure, utility, and limitations