General Chemistry II Course
Competencies
Lsn 12: Receptor Structure and Signal Transduction II
Intracellular Receptors and Zinc fingers
-
Diagram and effectively discuss the structure of zinc fingers; clearly
show the amino acid residues that interact with the zinc ion and how zinc
fingers affect protein shape
-
Explain the underlying basis for the zinc finger mechanism of action in
steroidal interactions with DNA
-
Discuss a new area of drug research that targets the zinc fingers in estrogen
receptors to treat breast cancer