Date

Lesson

1/15

1. Review: Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure

Text Assignment: GenChem - all applicable chapters;  MedChem - Chapter 2

 

1/17

2.  Intermolecular Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophic Interactions

1/22

3.  Solubility: Thermodynamics of Liquid-Lquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties

1/24

4.  Condensation and Hydrolysis Reactions:Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation

1/29

5.  Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and Hydrolysis

1/31

6.  Acid-Base Properties of Amino Acids:Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH

2/5

7.  Protein Structure: Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications

2/7

8.  Chemical Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular Distribution

2/12

9.  Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate Binding, Enzyme Inhibition, Competitive and Allosteric Inhibitors

2/14

10.  Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substate-Enzyme Affinity

2/19

11.  Mid-Term Exam

2/21

12.  Receptors as Drug Targets I: Neurotransmitters and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists, Sensitization, Tolerance, and Dependence

2/26

13.  Receptors as Drug Targets II: Affinity, Efficacy, and Potency; Dissociation Binding Equilibria, EC50, IC 50, and Scatchard Plots

2/28

14.  Receptor Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal) Receptors

3/4

15.  Receptor Structure and Signal Transduction II -  Ion Channels and Thermodynamics: Ion Concentration Gradients, Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes

3/6

16.  Receptor Structure and Signal Transduction III - GPCR's: G-Protein Coupled Receptors Signalzing Mechanism of Action

3/11

17.  Receptor Structure and Signal Transduction IV - Steroids and Intracellular Steroidal Receptors: Steroid Structure and Hydrophobicity, Complex Ions and Zinc Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment of Hormone-Dependent Breast Cancers

3/13

18.  Cholinergics I

3/25

19.  Cholinergics II

3/27

20.  Adrenergics I

4/1

21.  Adrenergics II

4/3

22.  Psychoactive Drugs I: Stimulants

4/8

23.  Psychoactive Drugs II: Anti-Depressants

4/10

24.  Psychoactive Drugs III: Hallucinogens

4/15

25.  Opium and Opioid Analgesics

4/17

26.  Chemistry of Local & General Anesthetics

4/22

27.  Test 2

4/24

28.  Review