General Chemistry II Syllabus for the Applied Medicinal Chemistry and Neuroscience Approach

1	Review: Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure
2	Intermolecular Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophic Interactions
3	Solubility: Thermodynamics of Liquid-Lquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties
4	Condensation and Hydrolysis Reactions:Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation
5	Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and Hydrolysis
6	Acid-Base Properties of Amino Acids:Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH
7	Protein Structure: Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications
8	Chemical Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular Distribution
9	Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate Binding, Enzyme Inhibition, Competitive and Allosteric Inhibitors
10	Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substate-Enzyme Affinity
11	Mid-Term Exam
12	Receptors as Drug Targets I: Neurotransmitters and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists, Sensitization, Tolerance, and Dependence
13	Receptors as Drug Targets II: Affinity, Efficacy, and Potency; Dissociation Binding Equilibria, EC50, IC 50, and Scatchard Plots
14	Receptor Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal) Receptors
15	Receptor Structure and Signal Transduction II - Ion Channels and Thermodynamics: Ion Concentration Gradients, Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes
16	Receptor Structure and Signal Transduction III - GPCR's: G-Protein Coupled Receptors Signalzing Mechanism of Action
17	Receptor Structure and Signal Transduction IV - Steroids and Intracellular Steroidal Receptors: Steroid Structure and Hydrophobicity, Complex Ions and Zinc Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment of Hormone-Dependent Breast Cancers
18	Cholinergics I
19	Cholinergics II
20	Adrenergics I
21	Adrenergics II
22	Psychoactive Drugs I: Stimulants
23	Psychoactive Drugs II: Anti-Depressants
24	Psychoactive Drugs III: Hallucinogens
25	Opium and Opioid Analgesics
26	Chemistry of Local & General Anesthetics
27	Test 2
28	Review