General Chemistry II Course
Competencies
Lsn 13: Nucleic Acid Drug Targets
Nucleic acid structure
-
Understand the structure of DNA and RNA to include the major components
and specific features
-
Understand the condensation mechanism of action to form phosphate diester
polynucleotides
-
Clearly explain the underlying physical basis for the attractions between
the two strands of double helix DNA
Central dogma
-
Understand and clearly describe how genetic information is encoded in DNA
-
Explain what a gene is, what it does, and the two roles of the major regions
(promoter and coding) of DNA gene templates
-
Generate a possible DNA sequence for the coding of a given peptide
-
Interpret a DNA or RNA sequence to generate an amino acid sequence that
is coded for by this
-
Complex ions
-
Understand the structure of complex ions and be able to explain the basis
for their interaction
-
Relate Lewis acid/base chemistry to complex ion components
-
Clearly explain why complexes are colored and demonstrate an understanding
of relevant molecular orbital energies
-
Show how transition metal ion valence electron energy levels shift as ions
are introduced into octahedral and tetrahedral ligand environments; understand
and be able to clearly explain the basis for these shifts
-
Understand and diagram the structure of important biochemical complexes
to include iron in hemoglobin, magnesium in chlorophyl and cobalt in B-12.
-
Outline the mechanism of action for platinum compounds [e.g. cisplatin
PtCl2(NH3)2] as chemotherapeutic agents
for cancer patients