CHEM106 General Chemistry II Course Competencies

Lsn 1: General Chemistry I Review: Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure


Lsn 2: Gen Chem I Review - Intermolecular Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions


Lsn 3: Solubility: Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties


Lsn 4: Condensation and Hydrolysis Reactions: Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation


Lsn 5: Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and Hydrolysis


Lsn 6: Acid-Base Properties of Amino Acids: Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH


Lsn 7: Protein Structure: Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications


Lsn 8: Chemical Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular Distribution


Lsn 9: Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate Binding, Enzyme Inhibition, Competitive and Allosteric Inhibitors


Lsn 10: Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, KM and Vmax Determination, Turnover Numbers, KM and Substrate-Enzyme Affinity


Lsn 11: Mid-Term Examination


Lsn 12: Receptors as Drug Targets I: Neurotransmitters and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists, Sensitization, Tolerance, and Dependence


Lsn 13: Receptors as Drug Targets II: Affinity, Efficacy, and Potency; Dissociation Binding Equilibria, EC50, IC 50, and Scatchard Plots


Lsn 14: Receptor Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal) Receptors


Lsn 15: Ion Channels and Thermodynamics I: Ion Concentration Gradients, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes


Lsn 16: Ion Channels and Thermodynamics II: Sodium-Potassium-ATP Pump Mechanism, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients


Lsn 17: Receptor Structure and Signal Transduction II – GPCR’s:  G-Protein Coupled Receptors Signaling Mechanism of Action


Lsn 18: Receptor Structure and Signal Transduction III: Steroids and Intracellular Steroidal Receptors: Steroid Structure and Hydrophobicity, Complex Ions and Zinc Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment of Hormone-Dependent Breast Cancers


Lsn 19: Cholinergics I: Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding


Lsn 20: Cholinergics II: Cholinergic Antagonists, Acetylcholinesterase Inhibitors


Lsn 21: Adrenergics: Geometry of adrenergic receptors, main types of norepinephrine receptors, interaction of adrenergic receptors with neurotransmitters, MOA of activated receptors


Lsn 22: Psychoactive Drugs I -- Stimulants and Tranquilizers:


Lsn 23: Psychoactive Drugs II – Anti-Depressants:


Lsn 24: Psychoactive Drugs III – Anti-Psychotics and Hallucinogens:


Lsn 25: Psychoactive Drugs IV – Opium and Opioid Analgesics:


Lsn 26: Chemistry of Local and General Anesthetics:


Lsn 27: Test 2


Lsn 28: Review