1. Serine has pKa's of 2.21 and 9.15.
a. Draw the three forms of serine that could
be present at various pH's. Show all bonds, atoms, and charges.
b. Draw the structure of serine that is most
prevalent at physiological pH.
c. Draw the structure of serine that would
be prevalent for a pH range of 1-2 (stomach).
d. For a pH of 10.15, draw and calculate the
ratio of the two most prevalent forms of serine.
2. Lysine has pKa's of 2.18, 8.95, and 10.53 (side chain).
a. Draw the structure of lysine that is most
prevalent at physiological pH.
b. Draw and calculate the ratio of the two
most prevalent forms of lysine at a pH of 4.0.