Cox-2 Inhibitors

Celebrex (Celocoxib)

INChI=1.12Beta/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18, 19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h1H3,2-10H,(H2,21, 24,25)

IUPAC Name = 4-[[5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]] benzenesulfonamide

Vioxx (Rofecoxib)

INChI=1.12Beta/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21- 17(18)16(15)13-5-3-2-4-6-13/h1H3,2-10H,11H2

IUPAC Name = 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one

Bextra (Valdecoxib)

INChI=1.12Beta/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19) 20)16(18-21-11)13-5-3-2-4-6-13/h1H3,2-10H,(H2,17,19,20)

IUPAC Name = 4-(5-methyl-3-phenyl-isoxazol-4-yl)benzenesulfonamide