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L1 M 1/10 L1 T 1/11 |
Lecture 1. General Chemistry Review Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure |
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L2 W 1/12 L2 R 1/13 |
Lecture 2. Intermolecular Forces (Noncovalent Interactions) Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions Text Assignment: MedChem – 1.3 (Intermolecular Bonding Forces); Atkins – 5.1-5.5 (Intermolecular Forces) |
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L3 T 1/18 L3 W 1/19 |
Lecture 3. Solubility and Lipids Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties Text Assignment: Atkins – 8.9 (The Like-Dissolves-Like Rule); MedChem – 18.2.1 (Hydrophobicity), 1.2.1 (Cell Structure) Link: UCSF Membrane Tutorial (Great resource!!) Reading: The Components and Properties of Cell Membranes Link: Kimball's Biology Pages: Fats (Unsaturated Fats, Trans and Omega Fatty Acids, Phospholipids |
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L4 R 1/20 L4 M 1/24 |
Lecture 4. Condensation and Hydrolysis Reactions Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation Handout: Condensation and Hydrolysis Reactions |
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L5 T 1/25 L5 W 1/26 |
Lecture 5. Amino Acids Structure, Chirality, Side Chain Polarity, Peptide Bond,Peptide Condensation and Hydrolysis, Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH Text Assignment: MedChem – Chapter 2 and Appendix 1 |
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L6 R 1/27 L6 M 1/31 |
Lecture 6. Protein Structure Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications Text Assignment: MedChem – Chapter 2 |
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L7 T 2/1 L7 W 2/2 |
Lecture 7. Enzymes: Structure and Function Enzyme Catalysis, Mechanism of Action, Active Site, Substrate Binding, Catalytic Roles, Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity Text Assignment: MedChem – Chapter 3 (Enzymes: Structure and Function) Text Assignment: Kimball's Biology Pages: Enzymes Text Assignment: Kimball's Biology Pages: Enzyme Kinetics |
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L8 R 2/3 L8 M 2/7 |
Lecture 8. Enzymes as Drug Targets Active Site Inhibitors, Allosteric Inhibition, Competitive / Uncompetitive / Non-Competitive Inhibitors, Suicidal Substrates Text Assignment: MedChem – Chapter 7 (Enzymes as Drug Targets) |
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L9 T 2/8 L9 W 2/9 |
Lecture 9. Medical Approaches to Inflammation I Cyclooxygenase Case Study Reading: Protein Function – Section III Cyclooxygenase (COX): An Example of How Enzymes Function Reading: Molecular Basis of Inflammation |
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L10 R 2/10 L10 M 2/14 |
Lecture 10. Medical Approaches to Inflammation II Steroids - Structure, Intracellular Receptors, Anti-Inflammatory MOA Reading: Molecular Basis of Inflammation Reading: Protein Function – Section II Nuclear Receptors: An Example of How Proteins Function Reading: Kimball's Biology Pages:Steroid Hormone Receptors and their Response Elements |
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L11 T 2/15 L11 W 2/16 |
Lecture 11. Receptors as Drug Targets I Neurotransmitters & Hormones, Agonists, Antagonists, Partial Agonists, Inverse Agonists, Treatment of Hormone-Dependent Breast Cancers Text Assignment: MedChem – Chapter 8, Sections 8.1-8.5 |
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L12 R 2/17 L12 M 2/21 |
Lecture 12. Receptors as Drug Targets II Desensitization & Sensitization; Tolerance & Dependence; Receptor Types & Subtypes; Affinity, Efficacy, & Potency; Ligand-Receptor Dissociation Equilibria, EC50, IC 50, Scatchard Plots Text Assignment: MedChem – Chapter 8, Sections 8.6-8.9 |
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L13 T 2/22 Quiz 6 L10-L12 L13 W 2/23 Quiz 6 L10-L12 |
Lecture 13. Nucleic Acids as Drug Targets Structure of DNA, Central Dogma, Intercalating Drugs, Alkylating & Metallating Agents, Cisplatin, 5-FU Text Assignment: MedChem – Chapter 6, Section 6.1 (Structure of DNA) Text Assignment: MedChem – Appendix 2 (The Standard Genetic Code) Text Assignment: MedChem – Chapter 9, Sections 9.1, 9.3 (Intercalating Drugs, Alkylating & Metallating Agents) Text Assignment: MedChem – Chapter 21, Section 21.2.3 (Alkylating & Metallating Agents) |
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T1 R 2/24 T1 M 2/28 |
Lecture 14. Receptor Structure and Signal Transduction I – Overview of Ion Channel Receptors Ion Concentration Gradients, Ion Channel Structure and Mechanisms of Action, Ligand-Gated and Voltage-Gated Ion Channels, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes, Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors) Text Assignment: MedChem – Appendix 4 (The Action of Nerves) UCSF Reading: “Diffusion and Transport Across Membranes” Section on Ion Channels (pages 80-86) |
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L14 T 3/1 L14 W 3/2 |
Mid-Term Examination on Material from Lectures 1-13 |
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L15 R 3/3 L15 M 3/7 |
Lecture 15. Receptor Structure and Signal Transduction II – Thermodynamics of Ion Channels Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors) Text Assignment: MedChem – Appendix 4 (The Action of Nerves) UCSF Reading: “Diffusion and Transport Across Membranes” Section on ATP-Driven Ion Pumps (pages 73-77) |
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L16 T 3/8 L16 W 3/9 |
Lecture 16. Receptor Structure and Signal Transduction III – G-Protein Coupled Receptors (GPCRs) G-Protein Coupled Receptor Structure, Evolutionary Tree of GPCRs, GPCR Signaling Mechanism of Action Text Assignment: MedChem – Section 4.7 (G-Protein Coupled Receptors) Text Assignment: MedChem – Section 5.1 (Signal Transduction Pathways for G-Protein Coupled Receptors) Text Assignment: MedChem – Section 5.2 (Signal Transduction Involving G-Proteins and Adenylate Cyclase) |
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L17 R 3/10 L17 M 3/21 |
Lecture 17. Receptor Structure and Signal Transduction IV – Kinase-Linked Receptors General Principles, Structure and Activation Mechanism of Tyrosine-Kinase Receptors, Tyrosine Kinase-Linked Receptors, Signal Transduction Involving Kinase-Linked Receptors Text Assignment: MedChem – Section 4.8 (Kinase-Linked Receptors) Text Assignment: MedChem – Section 5.4 (Signal Transduction Involving Kinase-Linked Receptors) |
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L18 T 3/22 L18 W 3/23 |
Lecture 18. Cholinergics I Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action of nerves) |
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L19 R 3/24 L19 M 3/28 |
Lecture 19. Cholinergics II Cholinergic Antagonists, Acetylcholinesterase Inhibitors Text Assignment: MedChem – Chapter 19 and Appendix 4 (The Action of Nerves) |
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L20 T 3/29 L20 W 3/30 |
Lecture 20. Adrenergics Geometry of Adrenergic Receptors, Main Types of Norepinephrine Receptors, Interaction of Adrenergic Receptors with Neurotransmitters, MOA of Activated Receptors Text Assignment: MedChem – Chapter 20 |
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L21 R 3/31 L21 M 4/4 |
Lecture 21. Psychoactive Drugs I: Stimulants and Tranquilizers Handout: |
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L22 T 4/5 L22 W 4/6 |
Lecture 22. Psychoactive Drugs II: Anti-Depressants Handout: |
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L23 R 4/7 L23 M 4/11 |
Lecture 23. Psychoactive Drugs III: Anti-Psychotics and Hallucinogens Handout: |
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L24 T 4/12 L24 W 4/13 |
Lecture 24. Psychoactive Drugs IV: Cannabinoids, Opium & Opioid Analgesics Cannabinoids, Source and History of Opiates, Structure of Opioids and Opioid Receptors, Endogenous Opioids, Side Effects of Opiates Text Assignment: MedChem – Chapter 21 |
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L25 R 4/14 L25 M 4/18 |
Lecture 25. Chemistry of Local & General Anesthetics MOA for Local Anesthetics, pKa Relevance, History of Cocaine Use by Humans, MOA for General Anesthetics, Molecular Structures of Widely Used General Anesthetics Handout: Local and General Anesthetics |
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T2 T 4/19 T2 W 4/20 |
Test 2 |
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R1 R 4/21 R1 M 4/25 |
Review |