L1 M 1/10

L1 T 1/11

    Lecture 1. General Chemistry Review

    Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure

L2 W 1/12

L2 R 1/13

    Lecture 2. Intermolecular Forces (Noncovalent Interactions)

    Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions

    Text Assignment: MedChem – 1.3 (Intermolecular Bonding Forces); Atkins – 5.1-5.5 (Intermolecular Forces)

L3 T 1/18

PS1 Due (1/18)

L3 W 1/19

PS1 Due (1/21)

    Lecture 3. Solubility and Lipids

    Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties

    Text Assignment: Atkins – 8.9 (The Like-Dissolves-Like Rule); MedChem – 18.2.1 (Hydrophobicity), 1.2.1 (Cell Structure)

    Link: UCSF Membrane Tutorial (Great resource!!)

    Reading: The Components and Properties of Cell Membranes

    Link: Kimball's Biology Pages: Fats (Unsaturated Fats, Trans and Omega Fatty Acids, Phospholipids

L4 R 1/20

PS2 Due

Quiz1

L4 M 1/24

PS2 Due

Quiz1

    Lecture 4. Condensation and Hydrolysis Reactions

    Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation

    Handout: Condensation and Hydrolysis Reactions

L5 T 1/25

PS3 Due

Quiz 2

L5 W 1/26

PS3 Due

Quiz 2

    Lecture 5. Amino Acids

    Structure, Chirality, Side Chain Polarity, Peptide Bond,Peptide Condensation and Hydrolysis, Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH

    Text Assignment: MedChem – Chapter 2 and Appendix 1

L6 R 1/27

PS4 Due

Quiz 3

L6 M 1/31

PS4 Due

Quiz 3

    Lecture 6. Protein Structure

    Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications

    Text Assignment: MedChem – Chapter 2

L7 T 2/1

Quiz 4

L7 W 2/2

Quiz 4

    Lecture 7. Enzymes: Structure and Function

    Enzyme Catalysis, Mechanism of Action, Active Site, Substrate Binding, Catalytic Roles, Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity

    Text Assignment: MedChem – Chapter 3 (Enzymes: Structure and Function)

    Text Assignment: Kimball's Biology Pages: Enzymes

    Text Assignment: Kimball's Biology Pages: Enzyme Kinetics

L8 R 2/3

PS5 Due

L8 M 2/7

PS5 Due

    Lecture 8. Enzymes as Drug Targets

    Active Site Inhibitors, Allosteric Inhibition, Competitive / Uncompetitive / Non-Competitive Inhibitors, Suicidal Substrates

    Text Assignment: MedChem – Chapter 7 (Enzymes as Drug Targets)

L9 T 2/8

PS6 Due

Quiz 5 L7-L8

L9 W 2/9

PS6 Due

Quiz 5 L7-L8

    Lecture 9. Medical Approaches to Inflammation I

    Cyclooxygenase Case Study

    Reading: Protein Function – Section III Cyclooxygenase (COX): An Example of How Enzymes Function

    Reading: Molecular Basis of Inflammation

L10 R 2/10

PS7 Due

L10 M 2/14

PS7 Due

    Lecture 10. Medical Approaches to Inflammation II

    Steroids - Structure, Intracellular Receptors, Anti-Inflammatory MOA

    Reading: Molecular Basis of Inflammation

    Reading: Protein Function – Section II Nuclear Receptors: An Example of How Proteins Function

    Reading: Kimball's Biology Pages:Steroid Hormone Receptors and their Response Elements

L11 T 2/15

L11 W 2/16

    Lecture 11. Receptors as Drug Targets I

    Neurotransmitters & Hormones, Agonists, Antagonists, Partial Agonists, Inverse Agonists, Treatment of Hormone-Dependent Breast Cancers

    Text Assignment: MedChem – Chapter 8, Sections 8.1-8.5

L12 R 2/17

L12 M 2/21

    Lecture 12. Receptors as Drug Targets II

    Desensitization & Sensitization; Tolerance & Dependence; Receptor Types & Subtypes; Affinity, Efficacy, & Potency; Ligand-Receptor Dissociation Equilibria, EC50, IC 50, Scatchard Plots

    Text Assignment: MedChem – Chapter 8, Sections 8.6-8.9

L13 T 2/22

Quiz 6 L10-L12

L13 W 2/23

Quiz 6 L10-L12

    Lecture 13. Nucleic Acids as Drug Targets

    Structure of DNA, Central Dogma, Intercalating Drugs, Alkylating & Metallating Agents, Cisplatin, 5-FU

    Text Assignment: MedChem – Chapter 6, Section 6.1 (Structure of DNA)

    Text Assignment: MedChem – Appendix 2 (The Standard Genetic Code)

    Text Assignment: MedChem – Chapter 9, Sections 9.1, 9.3 (Intercalating Drugs, Alkylating & Metallating Agents)

    Text Assignment: MedChem – Chapter 21, Section 21.2.3 (Alkylating & Metallating Agents)

T1 R 2/24

T1 M 2/28

    Lecture 14. Receptor Structure and Signal Transduction I – Overview of Ion Channel Receptors

    Ion Concentration Gradients, Ion Channel Structure and Mechanisms of Action, Ligand-Gated and Voltage-Gated Ion Channels, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes,

    Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors)

    Text Assignment: MedChem – Appendix 4 (The Action of Nerves)

    UCSF Reading: “Diffusion and Transport Across Membranes” Section on Ion Channels (pages 80-86)

L14 T 3/1

Midterm

L14 W 3/2

Midterm

    Mid-Term Examination on Material from Lectures 1-13

    A Few Practice Problems....

L15 R 3/3

L15 M 3/7

    Lecture 15. Receptor Structure and Signal Transduction II – Thermodynamics of Ion Channels

    Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes

    Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors)

    Text Assignment: MedChem – Appendix 4 (The Action of Nerves)

    UCSF Reading: “Diffusion and Transport Across Membranes” Section on ATP-Driven Ion Pumps (pages 73-77)

L16 T 3/8

L16 W 3/9

    Lecture 16. Receptor Structure and Signal Transduction III – G-Protein Coupled Receptors (GPCRs)

    G-Protein Coupled Receptor Structure, Evolutionary Tree of GPCRs, GPCR Signaling Mechanism of Action

    Text Assignment: MedChem – Section 4.7 (G-Protein Coupled Receptors)

    Text Assignment: MedChem – Section 5.1 (Signal Transduction Pathways for G-Protein Coupled Receptors)

    Text Assignment: MedChem – Section 5.2 (Signal Transduction Involving G-Proteins and Adenylate Cyclase)

L17 R 3/10

L17 M 3/21

    Lecture 18. Cholinergics I

    Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding

    Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action of nerves)

L18 T 3/22

L18 W 3/23

    Lecture 19. Cholinergics II

    Cholinergic Antagonists, Acetylcholinesterase Inhibitors

    Text Assignment: MedChem – Chapter 19 and Appendix 4 (The Action of Nerves)

L19 R 3/24

Quiz 7

L19 M 3/28

Quiz 7

    Lecture 20. Adrenergics

    Geometry of Adrenergic Receptors, Main Types of Norepinephrine Receptors, Interaction of Adrenergic Receptors with Neurotransmitters, MOA of Activated Receptors

    Text Assignment: MedChem – Chapter 20

L20 T 3/29

L20 W 3/30

    Compensatory Time for Review Paper Preparation

L21 R 3/31

L21 M 4/4

    Lecture 21. Psychoactive Drugs I: Stimulants and Tranquilizers

    Handout:

L22 T 4/5

L22 W 4/6

    Lecture 22. Psychoactive Drugs II: Anti-Depressants

    Handout:

L23 R 4/7

L23 M 4/11

    Lecture 23. Psychoactive Drugs III: Anti-Psychotics and Hallucinogens

    Handout:

L24 T 4/12

L24 W 4/13

    Lecture 24. Psychoactive Drugs IV: Cannabinoids, Opium & Opioid Analgesics

    Cannabinoids, Source and History of Opiates, Structure of Opioids and Opioid Receptors, Endogenous Opioids, Side Effects of Opiates

    Text Assignment: MedChem – Chapter 21

L25 R 4/14

L25 M 4/18

    Lecture 25. Chemistry of Local & General Anesthetics

    MOA for Local Anesthetics, pKa Relevance, History of Cocaine Use by Humans, MOA for General Anesthetics, Molecular Structures of Widely Used General Anesthetics

    Handout: Local and General Anesthetics

T2 T 4/19

T2 W 4/20

    Test 2

R1 R 4/21

Rev Paper Due

R1 M 4/25

Rev Paper Due

    Review