Course Lecture Schedule |
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L1 T 1/9 |
Lecture 1. General Chemistry Review Lewis Structures, Molecular Geometry, Arrhenius Equation, Second Law Text: Lewis Structures; Molecular Geometry; Chemical Kinetics; Acids & Bases, Chemical Thermodynamics Handout: Lewis Structure Methodology Wiki: Hybridization; Aromaticity; Arrhenius Equation; Second Law of Thermodynamics |
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L2 R 1/11 PS 1 Due |
Lecture 2. Intermolecular Forces (Noncovalent Interactions) Coulomb’s Law, Electronegativity, Hydrogen Bonds, Van der Waals Forces, Dipole-Dipole & Ion-Dipole Interactions, Solvation, Hydrophobicity Wiki: : Electronegativity; Intermolecular Forces; London Dispersion Forces; Hydrogen Bonds; Coulomb’s Law; Solvation; Hydrophobicity Text: Electronegativity, Intermolecular Forces (Hydrogen Bonding, Van Der Waals Forces, Dipole-Dipole & Ion-Dipole Interactions |
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L3 T 1/16 |
Lecture 3. Solubility and Lipids Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties Wiki: Partition Coefficient; Link: UCSF Membrane Tutorial (Great resource!!) Reading: The Components and Properties of Cell Membranes Link: Kimball's Biology Pages: Fats (Unsaturated Fats, Trans and Omega Fatty Acids, Phospholipids |
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L4 T 1/23 Quiz 1 |
Lecture 4. Condensation and Hydrolysis Reactions Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation Handout: Condensation Reactions |
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L5 R 1/25 Quiz 2 |
Structure, Chirality, Side Chain Polarity, Peptide Bond,Peptide Condensation and Hydrolysis, Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH Wiki: Amino Acids; Chirality; Peptide Bond; Henderson-Hasselbalch Equation; Link: Amino Acid Structures at pH=7.4 Amino Acid Chart with pKa Table |
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L6 T 1/30 Quiz 3 |
Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications Wiki: Protein Structure Disulfide Bonds Kimball's Biology Pages: Proteins; Polypeptides; Kimball's Biology Pages: Protein Structure: Primary; Secondary; Tertiary; Quaternary |
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L7 R 2/1 Quiz 4 |
Lecture 7. Chemical Kinetics McQuarrie Text Chapters 17 and 18 |
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L8 T 2/6 |
Lecture 8. Enzymes: Structure and Function Enzyme Catalysis, Mechanism of Action, Active Site, Substrate Binding, Catalytic Roles, Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity Text: Michaelis-Menten Model of Enzyme-Catalyzed Reactions Kimball's Biology Pages: Enzymes Kimball's Biology Pages: Enzyme Kinetics |
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L9 R 2/8 |
Lecture 9. Enzymes as Drug Targets Active Site Inhibitors, Allosteric Inhibition, Competitive / Non-Competitive Inhibitors, Suicidal Substrates Wiki: Enzymes; Enzyme Inhibitors |
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L10 T 2/13 Quiz 5
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Lecture 10. Medical Approaches to Inflammation I Cyclooxygenase Case Study Reading: Protein Function – Section III Cyclooxygenase (COX): An Example of How Enzymes Function Wiki: NSAIDs; COX-2 Inhibitors Reading: Molecular Basis of Inflammation |
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L11 R 2/15
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Lecture 11. Medical Approaches to Inflammation II Steroids - Structure, Intracellular Receptors, Anti-Inflammatory MOA Reading: Molecular Basis of Inflammation Reading: Protein Function – Section II Nuclear Receptors: An Example of How Proteins Function Reading: Kimball's Biology Pages: Steroid Hormone Receptors and their Response Elements Wiki: Steroid ; Zinc Finger; Complex Ion ; d-Orbitals |
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L12 T 2/20 Quiz 6 |
Lecture 12. Receptors as Drug Targets I Neurotransmitters & Hormones, Agonists, Antagonists, Partial Agonists, Inverse Agonists, Treatment of Hormone-Dependent Breast Cancers Wiki: Neurotransmitters; Hormones; Receptors; Antagonists; Agonists; Partial Agonists; Inverse Agonists; Ligands; Tamoxifen; Aromatase Inhibitors;
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L13 R 2/22 |
Lecture 13. Receptors as Drug Targets II Desensitization & Sensitization; Tolerance & Dependence; Receptor Types & Subtypes; Affinity, Efficacy, & Potency; Ligand-Receptor Dissociation Equilibria, EC50, IC 50 Wiki: Efficacy; Dose-Response Curve; EC50; IC50; Therapeutic Index; Scribd: Sensitization and Desensitization; |
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T1 T 2/27 Midterm |
Mid-Term Examination on Material from Lectures 1-13 |
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L14 R 3/1 |
Lecture 14. Nucleic Acids as Drug Targets Structure of DNA, Central Dogma, Intercalating Drugs, Alkylating & Metallating Agents, Cisplatin, 5-FU Wiki: Akylating Agents; Sulfur Mustard; Cisplatin; |
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L15 T 3/6 |
Lecture 15. Receptor Structure and Signal Transduction I – Overview of Ion Channel Receptors Ion Concentration Gradients, Ion Channel Structure and Mechanisms of Action, Ligand-Gated and Voltage-Gated Ion Channels, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes, Wiki: Ion Channels; Nernst Equation; Action Potential ; K+ Ion Channel Nobel Chemistry Lecture (Video) UCSF Reading: “Diffusion and Transport Across Membranes” Section on Ion Channels (pages 80-86) |
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L16 R 3/8 |
Lecture 16. Receptor Structure and Signal Transduction II – Thermodynamics of Ion Channels Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes UCSF Reading: “Diffusion and Transport Across Membranes” Section on ATP-Driven Ion Pumps (pages 73-77) Wiki: Neuron; Membrane Potential; Na+/K+-ATPase McGraw-Hill: Sodium-Potassium-ATP Pump |
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L17 T 3/20
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Lecture 17. Receptor Structure and Signal Transduction III – G-Protein Coupled Receptors (GPCRs) G-Protein Coupled Receptor Structure, Evolutionary Tree of GPCRs, GPCR Signaling Mechanism of Action 2012 Nobel Chemistry - Nobel Lecture Rob Lefkowitz Nobel Lecture Brian Kobilka |
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L18 R 3/22 Quiz 7 |
Lecture 18. Cholinergics Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding, Cholinergic Antagonists, Acetylcholinesterase Inhibitors |
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L19 T 3/27 |
Lecture 19. Adrenergics Geometry of Adrenergic Receptors, Main Types of Norepinephrine Receptors, Interaction of Adrenergic Receptors with Neurotransmitters, MOA of Activated Receptors |
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L20 R 3/29 |
Lecture 20. Psychoactive Drugs I: Stimulants and Tranquilizers Handout: |
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L21 T 4/3 |
Lecture 21. Psychoactive Drugs II: Anti-Depressants Handout: |
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L22 R 4/5 |
Lecture 22. Psychoactive Drugs III: Anti-Psychotics and Hallucinogens Handout |
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L23 T 4/10 |
Lecture 23. Psychoactive Drugs IV: Cannabinoids, Opium & Opioid Analgesics Cannabinoids, Source and History of Opiates, Structure of Opioids and Opioid Receptors, Endogenous Opioids, Side Effects of Opiates Text Assignment: MedChem – Chapter 21 |
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L24 R 4/12 |
Lecture 24. Chemistry of Local & General Anesthetics MOA for Local Anesthetics, pKa Relevance, History of Cocaine Use by Humans, MOA for General Anesthetics, Molecular Structures of Widely Used General Anesthetics Handout: Local and General Anesthetics |
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T2 T 4/17 |
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R1 R 4/19 |
Review |
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