Date |
Lesson |
1/15 |
1. Review: Electronegativity,
Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization,
Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and
Vapor Pressure Text Assignment: GenChem
- all applicable chapters; MedChem - Chapter 2 |
1/17 |
2. Intermolecular
Forces (Noncovalent Interactions): Ionic
Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole
Interactions, Repulsive Interactions, Water Solvation,
and Hydrophic Interactions |
1/22 |
3. Solubility: Thermodynamics of
Liquid-Lquid Solubility, Octanol-Water
Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane
Structure and Properties |
1/24 |
4. Condensation
and Hydrolysis Reactions:Alcohols and Carboxylic
Acids, Triglyceride Formation, Polyphosphate and Phospholipid
Formation |
1/29 |
5. Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and
Resonance, Peptide Condensation and Hydrolysis |
1/31 |
6. Acid-Base
Properties of Amino Acids:Henderson-Hasselbalch Equation, Charge
and pH, Solubility and pH |
2/5 |
7. Protein
Structure: Primary Structure, Disulfide Bonds, Secondary Structure
- Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and
Associated Noncovalent Interactions, Prions, PostTranslational
Protein Modifications |
2/7 |
8. Chemical
Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular
Distribution |
2/12 |
9. Enzyme
Catalysis: Enzyme Catalysis Mechanism of Action, Active Site
Substrate Binding, Enzyme Inhibition, Competitive and Allosteric
Inhibitors |
2/14 |
10. Enzyme
Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax
Determination, Turnover Numbers, Km and Substate-Enzyme
Affinity |
2/19 |
11. Mid-Term Exam |
2/21 |
12. Receptors as
Drug Targets I: Neurotransmitters and Hormones, Ion Channel and
Membrane receptors, Receptor-Ligand Interactions,
Agonists and Antagonists, Sensitization, Tolerance, and Dependence |
2/26 |
13. Receptors as
Drug Targets II: Affinity, Efficacy, and Potency; Dissociation
Binding Equilibria, EC50, IC 50, and Scatchard Plots |
2/28 |
14. Receptor
Structure and Signal Transduction I: Overview of Ion Channels,
G-Protein Coupled Receptors, Kinase-Linked
Receptors, Intracellular (Steroidal) Receptors |
3/4 |
15. Receptor
Structure and Signal Transduction II -
Ion Channels and Thermodynamics: Ion
Concentration Gradients, Sodium-Potassium-ATP Pump Mechanism, Cell Membrane
Potentials, Nernst Equation and Membrane
Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage
and Concentration Gradients, Ion Movements and Resulting
Inhibitory/Excitatory Potential Changes |
3/6 |
16. Receptor
Structure and Signal Transduction III - GPCR's: G-Protein
Coupled Receptors Signalzing Mechanism of Action |
3/11 |
17. Receptor Structure
and Signal Transduction IV - Steroids and Intracellular Steroidal Receptors: Steroid
Structure and Hydrophobicity, Complex Ions and Zinc
Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment
of Hormone-Dependent Breast Cancers |
3/13 |
18. Cholinergics I |
3/25 |
19. Cholinergics II |
3/27 |
20. Adrenergics I |
4/1 |
21. Adrenergics II |
4/3 |
22. Psychoactive
Drugs I: Stimulants |
4/8 |
23. Psychoactive
Drugs II: Anti-Depressants |
4/10 |
24. Psychoactive Drugs
III: Hallucinogens |
4/15 |
25. Opium and Opioid Analgesics |
4/17 |
26. Chemistry of
Local & General Anesthetics |
4/22 |
27. Test 2 |
4/24 |
28. Review |