Chemistry 307: Bioorganic Chemistry

Dr. T. Christian Grattan/Dr. Jason Hurlbert (SIMS 301B)

Spring 2017 Winthrop University

MWF 12:30-1:20 PM (OWENS 102)

 

Textbooks: Organic Chemistry, 6th ed., Loudon REQUIRED

 

Course objectives: My goal for this course is to clearly explain the fundamental concepts of bioorganic chemistry and help to provide a bridge between organic and biochemistry.  The students should be able to achieve a working understanding of the structure, function and reactivity for carbohydrates, lipids, proteins and nucleic acids. The students will also investigate the mechanisms of coenzymes and examine the basics of drug discovery.

 

Office Hours: Dr. Grattan: M 11:00 AM–12:00 PM; T 10:00–11:00 AM; W 11:00–12:00 PM; Dr. Hurlbert MWF 1:00 – 2:00 PM or by appointment (Grattan: 323-4927 or grattanc@winthrop.edu, Hurlbert: 323-4928 or hurlbertj@winthrop.edu)

We will also be accessible to answer questions on email.  You will find that this course is different than any other courses you have taken in college.  It is therefore important to stay on top of the material and get your questions answered as soon as possible.  Please take advantage of our office hours or email to resolve these problems.

 

Attendance: Due to the unique nature of this course, each and every class meeting is important to better understand the material in the text. The students are responsible for all assignments for the course regardless of absence. 

 

Homework and Assignments: Problems will be assigned for each chapter in the text. It is very important to understand the problems that are assigned, as they will be similar to those on the problem sets and exams. You are strongly encouraged to work and study in groups!! These assignments will be graded. Failure to turn in a problem set by the assigned time will result in a 5% penalty/day.

 

Grading System:

3 in-class Exams (100 points each)

300 points

Homework set average

100 points

Final Exam

200 points

Total

600 points

 

Grading Scale:

Percentage

Grade

Percentage

Grade

93-100%

A

77-79%

C+

90-93%

A-

70-76%

C

87-89%

B+

60-69%

D

83-86%

B

<60%

F

 

Exams: This course will consist of three one hour and fifteen minute in-class exams and one cumulative final exam given on the dates provided. Exam problems will be similar to the assigned problems. Each exam is limited to the allotted class time and the final exam will be limited to two and one-half hours. Make up exams will be given only with a valid excuse such as a severe personal or family crisis.

 

Exam 1

Monday, January 30

12:30 – 1:45 PM

Exam 2

Monday, February 27

12:30 – 1:45 PM

Exam 3

Friday, April 7

12:30 – 1:45 PM

Final Exam

Tuesday, May 2

11:30 – 2:00 PM

 

Cheating: Infractions of academic discipline are dealt with in accordance with the student Academic Misconduct Policy which is in the Student Conduct Code in the Student Handbook. Academic misconduct includes, but is not limited to,

providing or receiving assistance in a manner not authorized by the professor in the creation of work to be submitted for academic evaluation including papers, projects, and examinations; presenting, as one’s own, the ideas or words of

another for academic evaluation without proper acknowledgment; doing unauthorized academic work for which another person will receive credit or be evaluated; and presenting the same or substantially the same papers or projects

in two or more courses without the explicit permission of the professors involved. In addition, academic misconduct involves attempting to influence one’s academic evaluation by means other than academic achievement or merit.

 

S/U and Withdrawal Policy: According to University policy, Friday January 13, 2017 is the last day to drop this course. Wednesday, March 8, 2017 is the last day to withdraw from a spring semester course or to declare S/U for the course.

 

Students with Disabilities Policy: Winthrop University is committed to providing access to education.  If you have a condition which may adversely impact your ability to access academics and/or campus life, and you require specific accommodations to complete this course, contact the Office of Accessibility (OA) at 803-323-3290, or, accessibility@winthrop.edu. Please inform me as early as possible, once you have your official notice of accommodations from the Office of Accessibility.

 

Student code of conduct: As noted in the Student Code of Conduct: Responsibility for good conduct rests with students as adult individuals. Violations of the code of conduct found in the Student Conduct Code Academic Misconduct Policy will be dealt with as described in the policy.

 

Academic Success Center: Winthrop’s Academic Success Center is a free resource for all undergraduate students seeking to perform their best academically. The ASC offers a variety of personalized and structured resources that help students achieve academic excellence, such as tutoring, academic skill development (test taking strategies, time management counseling, and study techniques), group and individual study spaces, and academic coaching. The ASC is located on the first floor of Dinkins, Suite 106.  Please contact the ASC at 803-323-3929 or success@winthrop.edu. For more information on ASC services, please visit www.winthrop.edu/success.

Winthrop University’s Office of Nationally Competitive Awards (ONCA) identifies and assists highly motivated and talented students to apply for nationally and internationally competitive awards, scholarships, fellowships, and unique opportunities both at home and abroad. ONCA gathers and disseminates award information and deadlines across the campus community, and serves as a resource for students, faculty, and staff throughout the nationally competitive award nomination and application process. ONCA is located in Dinkins 222B. Please fill out an online information form at the bottom of the ONCA webpage www.winthrop.edu/onca and email onca@winthrop.edu for more information.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CHEM 307 Class Lecture/Exam Schedule

Date

Topic

9-Jan

Introduction, Carbohydrate structure

11-Jan

Redox reactions, Chain length reactions

13-Jan

Cyclization, Glycoside formation

16-Jan

MLK Jr Day – OFF

18-Jan

Classification/Structure of Amino Acids, Acid-Base Behavior

20-Jan

Synthesis of Amino Acids/Peptides

23-Jan

Solid Phase Synthesis of Peptides

25-Jan

Peptide Structure and Folding

27-Jan

Sanger Method, Enzymatic Sequencing Methods

30-Jan

Exam 1

1-Feb

Computer Lab–Using Chimera to Visualize Protein Structure

3-Feb

Structure and Function of Lipids

6-Feb

Terpenes and Lipid Biosynthesis

8-Feb

Steroids and Synthesis

10-Feb

Biological Membranes

13-Feb

Membrane Transport

15-Feb

Nucleic Acids, Nucleosides and Nucleotides

17-Feb

PCR, Biosynthesis of DNA/RNA

20-Feb

Biosynthesis of Proteins, DNA Fingerprinting

22-Feb

Lab Synthesis of DNA Strands, DNA Based Drug Interaction

24-Feb

Review

27-Feb

Exam 2

1-Mar

Catalysis - Acid/Base/Nucleophilic

3-Mar

Catalysis - Metal Ion/Intermolecular/Intramolecular

6-Mar

Binding Sites

8-Mar

Enzyme Catalyzed Reactions

10-Mar

Enzyme Catalyzed Reactions

13-17-Mar

SPRING BREAK – OFF

20-Mar

Computer Lab-Active Site Investigations

22-Mar

Org Mech of Coenzymes - Cofactors/Vitamin B12, THF, TS

24-Mar

Vitamin K, H, B2, B1

27-Mar

Vitamin B3, PLP, Coenzyme A

29-Mar

Metabolic Pathways - ATP, Catabolism

31-Mar

Catabolism of Fats, Carbohydrates, Proteins

3-Apr

Citric Acid Cycle, Oxidative Phosphorylation, Anabolism

5-Apr

Review

7-Apr

Exam 3

10-Apr

Drug Discovery

12-Apr

Lead Modification, SAR

14-Apr

Increasing Oral Bioavailability

17-Apr

Genomics and Proteomics

19-Apr

Computer Lab - HIV Inhibitors/Py Rx

21-Apr

Computer Lab - HIV Inhibitors/Py Rx

24-Apr

Final Review

2-May

Final Exam (11:30 AM)