Chemistry 502 - Instrumental Methods of Analysis – Spring 2003


Qualitative and quantitative methods of chemical analysis for organic, biochemical, and inorganic compounds fall into two categories, classical (or wet) methods and instrumental methods. Chemistry 313 surveyed many classical methods and some instrumental methods of analysis. Although there is not always a clear barrier between the two, the primary difference arises from the type of physical property used to provide information. Classical methods often rely on reactivity or physical properties such as solubility, melting and boiling points, odors, or refractive indices for qualitative information, while gravimetric, volumetric, and titrimetric measurements provide quantitative information.  Classical methods for the separation of mixtures are mainly solvent extractions or distillations. Instrumental methods typically utilize other physical properties such as absorption or emission of light, mass-to-charge ratio, or electrode potential.  Separations are carried out by more efficient chromatographic methods.

Instrumental methods certainly extend well beyond the chemistry lab. These instruments are found in biotechnology, environmental, geological, materials, forensic, medical, nutritional, and industrial labs. Unfortunately, some scientists view and utilize these instruments as "black boxes". This term implies a device in which the scientist places a sample and somehow a number is generated that influences the scientist’s decision-making process. It should be apparent that this approach could be dangerous, as the old saying "Garbage In/Garbage Out" is often true. As such any scientist using such sophisticated equipment needs at least a basic understanding of how these instruments work.

Instrumental Methods of Analysis is a broad subject, but the methods are generally categorized as either spectroscopic, electrochemical, or chromatographic.  We will essentially take the cover off the "black box" and see how these instruments are constructed and measurements made from the underlying chemical and physical properties of the substance.  Quantitative problem solving will be utilized as a means to demonstrate physical principles applied in the design and performance of instruments.

The goal of this course is not to make you an "expert" on each type of instrumentation encountered, but rather to introduce and educate you to the many types of instruments available for chemical analysis and the type(s) of information these instruments provide. It is my hope that you will then expand your knowledge of the instruments you come into contact with during your scientific career, thereby avoiding the "black box" problem.

 

Specific Course Objectives:

By the end of this course, you should:


Time/Location: 11:00 - 12:15 TR / Sims 301-B

Professor: Dr. C. Calloway callowayc@winthrop.edu

Office: 312-B Sims Hall; 323-4945

Office Hours: TRF 8:00 - 10:00 a.m. {and other times by appointment.}

Textbook: Principles of Instrumental Analysis, 5thedition,Skoog, D.A., Holler, F.J., Nieman, T.A.

You may find the website, "Chemistry Hypermedia Project" (Analytical Chemistry Tutorial), a useful tool.


Grading/Evaluation:

Note:  Since all graded work (including homework to be collected, quizzes, papers, mid-term examinations, final examination, research proposals, laboratory results and reports, etc.) may be used in the determination of academic progress, no collaboration on this work is permitted in this course unless the instructor explicitly indicates that some specific degree of collaboration is allowed. This statement is not intended to discourage students from studying together, seeking help from the instructor, or working together on assignments that are not to be collected.

 

 

 

Grades in this course will be determined from three sources, as follows:

 Letter grades will be assigned as follows:

90 - 100%:        A

80-89%:           B

70-79%:           C

60-69%:           D


Menu of Topics:

Exam 1

Exam 2

Exam 3

Exam 4

Students with Disabilities: If you have a disability and need classroom accommodations, please contact Services for Students with Disabilities, at 323-2233, as soon as possible.  Once you have your “professor notification letter”, please notify me so that I am aware of your accommodations well before the first test.


My advice, to help you succeed in this endeavor:


We, the members of the Winthrop University Community, pledge to hold ourselves and peers to the highest standards of honesty and integrity


Instrumental Analysis Student Competencies

Principles of Instrumental Analysis, 5th. Ed., Douglas A. Skoog, F. James Holler, Timothy A. Nieman, 1998.

Chapter 1 Student competencies

Upon completion of this chapter, students should be able to:

Chapter 2 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

 Chapter 5 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 6 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 7 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 8 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 9 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 10 Student competencies

Upon completion of this chapter, students should be able to:  

 

 

Chapter 13 Student competencies

Upon completion of this chapter, students should be able to:  

 

Chapter 14 Student competencies

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Chapter 15 Student competencies

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Chapter 16 Student competencies

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Chapter 17 Student competencies

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Chapter 18 Student competencies

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Chapter 19 Student competencies

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Chapter 11 Student competencies

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Chapter 20 Student competencies

Upon completion of this chapter, students should be able to:  

 

Chapter 21 Student competencies

Upon completion of this chapter, students should be able to: